Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication.

By Biao Chen, D. Dowlatshahi, G. MacQueen, Jun-feng Wang, L. Young. Biological Psychiatry, 2001

1,186 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/f4ec828681266b7c9eed300056f7e6b42a997a48

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In Biological Psychiatry

In Cellular and Molecular Neuroscience

Citations in the corpus

Posttraumatic stress disorder: a state-of-the-science review. (2006, methodology): “, 1999; Chen et al., 2001). Finally, the changes appear to persist over time; decreased activity in area 25 was seen 18 months later (Mayberg, 2003; Liotti et al., 2000) (Fig. 9—Mayberg et al., 2000a,b; Mayberg et al., 2002; Liotti et al., 2002a,b; Stefurak and Mayberg, 2003; Goldapple et al., 2004a”
BDNF — a key transducer of antidepressant effects (2015, background): “…immunoreactivity is increased in several hippocampal regions including the DG in patients treated with antidepressants at the time of their death (Chen et al., 2001) suggesting that BDNF in the hippocampus, specifically in particular subregions, may be critical for antidepressant responses in…”
Potential therapeutic uses of BDNF in neurological and psychiatric disorders (2011, background): “BDNF levels are also elevated in the hippocampi of patients treated with antidepressant”
New insights into BDNF function in depression and anxiety (2007, background): “Thus, compared with normal human subjects, levels of BDNF are lower in postmortem brain tissue from depressed patients but higher in those who were taking antidepressants at the time of deat”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “…CREB, which has a well-established role in learningrelated synaptic plasticity in many organisms and brain regions (eg Bartsch et al, 1998; Pittenger et al, 2002; reviewed in Carlezon et al, 2005) and is involved in the hippocampus in antidepressant response (Thome et al, 2000; Chen et al, 2001a).”
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus (2005, background): “…the mRNA for BDNF and its receptor trkB in the hippocampus (Nibuya et al., 1995; Russo-Neustadt et al., 2000), and BDNF protein levels are increased in postmortem brain samples of depressed patients treated with antidepressants when compared with nontreated depressed patients (Chen et al., 2001).”
NMDA Receptor Blockade at Rest Triggers Rapid Behavioural Antidepressant Responses (2011, neutral): “0001 for duration of response; F(9,81) 5 9.”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “Moreover, postmortem studies have shown that patients who were depressed at the time of death have decreased levels of BDNF as well as TrkB (”
Role of neurotrophic factors in depression. (2007, background): “BDNF in depression and stress In humans, brain BDNF levels have been found to be reduced in postmortem samples from depressed patients, and antidepressant therapy restores brain BDNF levels to the normal range [2,5].”