Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.

By Stephanie K. Bunt, Lingling Yang, P. Sinha, V. Clements, Jeff Leips, S. Ostrand-Rosenberg. Cancer Research, 2007

669 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f4cc3e6ca2c499032c603d33e80a6927988a5354

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Citations in the corpus

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “We and others recently demonstrated that the inflammatory mediators IL-1 , IL-6, and PGE2 induce accumulation of myeloid-derived suppressor cells (MDSC) in tumorbearing individuals.”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Therefore, similarly as IL-1 , IL-6, and PGE2, S100A8/A9 proteins facilitate the accumulation of MDSC.”
Tumor-derived granulocyte-macrophage colony stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer (2012, background): “Mice lacking the IL-1 receptor exhibit delayed accumulation of MDSC and slower progression of implanted 4T1 mammary tumors and interestingly, these effects are partially restored by exogenous administration of IL-6, indicating that IL-6 may contribute independently to MDSC expansion (Bunt et al., 20”
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia (2012, background): “…to induce the accumulation of Gr1+CD11b+ myeloid cells and the concomitant suppression of T cell immune response in a variety of mouse tumor models (Bunt et al., 2007; Melani et al., 2003; 844 Cancer Cell 21, 836–847, June 12, 2012 ª2012 Elsevier Inc. Pilon-Thomas et al., 2011; Tu et al., 2008).”
Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. (2008, background): “, 2005), while 4T1 mammary carcinoma tumors implanted into IL-1R-deficient mice exhibit delayed accumulation of MDSCs and slower-growing tumors (Bunt et al., 2007).”
Microenvironmental regulation of metastasis (2009, background): “Chronic inflammation has been shown to induce MDSC accumulation in the 4T1 metastatic mammary cancer mode”
Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy (2011, background): “In contrast, immunosuppressive CD11bLy6G cells are more abundant in other mammary tumor models, such as 4T1 (41).”
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “MDSCs are Gr-1 CD11b immature myeloid cells that have been associated with tumor development and growth (40, 356, 357) and with IL-1 (40, 290).”