Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism

By C. Werts, R. Tapping, J. Mathison, T. Chuang, V. Kravchenko, I. Girons, David A. Haake, P. Godowski, F. Hayashi, A. Ozinsky and 6 more. Nature Immunology, 2001

768 citations recorded by the source corpus.

Subfields: Infectious Diseases, Parasitology

View Paper: https://www.semanticscholar.org/paper/f49b8dc4aea97b532d08f9783a947318394e13c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. R. Medzhitov
2. Shizuo Akira

In Parasitology

1. David A. Haake
2. P. Levett
3. R. Medzhitov

Citations in the corpus

• Innate immune recognition. (2002, background): “The list includes peptidoglycan (73, 77), bacterial lipoproteins (78–80), a phenol soluble factor from Staphylococcus epidermidis (81), LPS from Prophyromonas gingivitis (82) andLeptospira interrogans(which differs in structure from the LPS of gram-negative bacteria) (83), glycosylphosphotidylinosit”
• Leptospira and Leptospirosis. (2020, background): “In addition, it has been shown that the leptospiral LPS, in contrast to other gram-negative bacteria, escapes human TLR4 recognition [15], and is recognized by TLR2 in human cells [16].”
• Toll-like receptors and innate immunity (2001, background): “In addition, TLR2 functions as a receptor for atypical LPS produced by Leptospira interrogans”
• Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. (2007, background): “In addition to TLR-4, TLR-2 reportedly acts as a receptor for endotoxin as well as various other microbial products and lipoproteins [18–20].”
• Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock (2003, background): “However, LPS from Leptospira interrogans (587) and Porphyromonas gingivalis (22) have been found to act exclusively through TLR2.”
• Leptospira and leptospirosis. (2001, neutral): “Whether this reduced biological activity is due to unique properties of leptospiral Lipid A (Que-Gewirth et al., 2004; Werts et al., 2001) remains unknown.”
• Leptospirosis in Humans (2015, positive): “For example, Fukumura (1984) reported that individuals immunized with a serovar Pyrogenes vaccine were protected from infection by that serovar but not from serovars Autumnalis and Hebdomadis with antigenically unrelated LPS, leading to development of a trivalent vaccine consisting of all three sero”