Signal Peptide-Dependent Protein Transport inBacillus subtilis: a Genome-Based Survey of the Secretome

By H. Tjalsma, A. Bolhuis, J. Jongbloed, S. Bron, J. V. van Dijl. Microbiology and Molecular Biology Reviews, 2000

855 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f4252767d0e559c99d9ca5ad0cad9b4db758a840

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Citations in the corpus

Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systems (2006, background): “Before translocation through the cell membrane, these proteins remain unfolded in the cell and fold outside the cytoplasm after proteolytic removal of the signal peptide (Tjalsma et al. 2000).”
The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa. (2002, background): “Bacillus subtilis secretes about 300 proteins, the vast majority co-translationally as in eukaryotes, not post-translationally as in proteobacteria like Escherichia coli (Tjalsma et al., 2000).”
Feature-based prediction of non-classical and leaderless protein secretion. (2004, background): “With the excessive complexity of the secretome, which by definition comprises the secretory proteins and the secretion machinery (Tjalsma et al., 2000; Antelmann et al., 2001; Greenbaum et al., 2001), no current computational prediction method is able to cover all targeting signals.”
The Crystal Structure of Bacillus subtilis Lipase : A Minimal α/β Hydrolase Fold Enzyme (2001, background): “The organism is of substantial commercial interest because of its highly ef®cient protein secretion system.(1) It is used, for instance, for the production of bulk quantities of proteases and amylases.”
Proteomics of Protein Secretion by Bacillus subtilis: Separating the “Secrets” of the Secretome (2004, background): “Proteins retained at the membrane/cell wall interface include substrate-binding proteins, chaperones for protein secretion, RNases, DNases, enzymes involved in the synthesis of peptidoglycan (penicillinbinding proteins), and cell wall hydrolases, which are involved in cell wall turnover during cell ”
PrediSi: prediction of signal peptides and their cleavage positions (2004, neutral): “Agreeing with earlier analysis, signal peptides of Gram-positives are larger than those of other organisms (12).”
Bacterial cell attachment, the beginning of a biofilm (2007, background): “The problem remains that cells contain many complicated surface structures such as flagella, pili, fimbriae, glycoproteins, carbohydrates, teichoic acids and other biological materials composed of proteins in Bacillus species up to 9% of total cell proteins are associated with the cell wall [104].”