Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systems

By K. Terpe. Applied Microbiology and Biotechnology, 2006

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Production of recombinant proteins by microbes and higher organisms. (2009, background): “E. coli is one of the earliest and most widely used hosts for the production of heterologous proteins (Terpe, 2006).”
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications (2019, background): “coli has some disadvantages, such as endotoxins production, difficulty in disulfide bonds expression, and acetate formation, which has toxic effects [85,86].”
Exogenous Enzymes as Zootechnical Additives in Animal Feed: A Review (2021, background): “Despite this, bacterial expression systems remain attractive due to their rapid growth, use of inexpensive culture media, genetic characterization, number of cloning vectors and mutant host strains [112].”
Bacillus subtilis A Potential Probiotic Bacterium to Formulate FunctionalFeeds for Aquaculture (2014, background): “subtilis strains with overproduction of antimicrobial peptides or enzymes already exist scientifically and commercially, but only their products are being sold not the strains [12,23,44,45].”