Geometric cues for directing the differentiation of mesenchymal stem cells

By K. Kilian, Branimir Bugarija, B. Lahn, M. Mrksich. Proceedings of the National Academy of Sciences of the United States of America, 2010

1,794 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Genetics

View Paper: https://www.semanticscholar.org/paper/f3e4c7602df759538031ada98fdc8c33275ddb14

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Citations in the corpus

Forming functional fat: a growing understanding of adipocyte differentiation (2011, background): “Single human MSCs plated on small surfaces that lead to a rounded morphology express pro-adipogenic WNT genes (see above) and differentiate into adipocytes upon dual adipogenic–osteogenic stimulatio”
Modulation of macrophage phenotype by cell shape (2013, background): “Cell shape changes have been associated with different functional states of cells (8), including proliferation and apoptosis (9), nuclear organization (10), stem cell differentiation (11, 12), and muscle cell contractility (13).”
Engineering microscale topographies to control the cell–substrate interface (2012, background): “On a cellular level, there is mounting evidence that mechanical cues affect cellular proliferation [174], morphogenesis [175], migration [138], and stem cell differentiation [151,176].”
Extracellular matrix: A dynamic microenvironment for stem cell niche (2014, neutral): “cell rounding promotes adipogenesis [99].”
Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency. (2011, background): “Key observations have included chemical (microcontact printed patterns of fibronecti”
Engineering microfluidic concentration gradient generators for biological applications (2013, neutral): “…species (Keenan, Hsu et al. 2006; Hamid, Blencowe et al. 2010; Suri and Schmidt 2010) and biophysical cues (Guilak, Cohen et al. 2009; Tripathi, Kathuria et al. 2009; Connelly, Gautrot et al. 2010; Kilian, Bugarija et al. 2010), thereby mimicking the in-vivo microenvironment of specific cell types.”
Nanotopography-guided tissue engineering and regenerative medicine (2012, background): “Recently, several in vitro studies with microfabrication tools demonstrated that cell shape, independent of soluble factors, has a strong influence on the osteogenic differentiation and commitment of stem cells [93,153,154].”
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues (2012, methodology): “The images in the Figure were adapted with permission from Kilian et al., 2010 (A), Desai et al., 2009 (B), Fu et al., 2010 (C), Bettinger et al., 2009 (E), Teixeira et al., 2003 (F), Gómez-Sjöberg et al., 2007 (G) (Kilian et al., 2010; Desai et al., 2009; Fu et al., 2010; Bettinger et al., 2009;…”
2D and 3D cell cultures – a comparison of different types of cancer cell cultures (2016, background): “The changed morphology of the cells can affect their function [16, 17], the organization of the structures inside the cell, secretion and cell signalling [18, 19].”
Micropatterning as a tool to decipher cell morphogenesis and functions (2010, background): “In mesenchymal cells, high levels of myosin II decoration on stress fibers are observed in elongated cells compared with round cells, suggesting that elongated cells are more contractile (Kilian et al., 2010).”