Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

By I. Chessell, J. Hatcher, C. Bountra, A. Michel, J. Hughes, P. Green, Julie Egerton, Melanie Murfin, J. Richardson, Wendy L. Peck and 6 more. Pain, 2005

808 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/f3a45aadcab8b2e9a2e435b33c45c290a9ef9b18

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. G. Burnstock
2. Arne May
3. Joanna Mika

In Physiology

1. G. Burnstock
2. G. Núñez
3. L. Franchi
4. C. A. Dinarello
5. Arne May
6. Joanna Mika
7. W. Junger
8. Guo-Yuan Yang

Citations in the corpus

• The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. (2010, neutral): “Luongo et al. (2010), Romero-Sandoval et al. (2008b) Purinoceptor antagonists (P2X7 antagonists; A-438079) (P2Y12 antagonists; MRS2395, AR-C69931MX, Clopidogrel) Prevent activation of microglia by ATP.”
• Pathophysiology and Therapeutic Potential of Purinergic Signaling (2006, background): “ropathic pain (Chessell et al., 2005).”
• Cellular and Molecular Mechanisms of Pain (2009, neutral): “, 2003), P2X7 (Chessell et al., 2005), and P2Y12 (Haynes et al.”
• Purinergic signalling and disorders of the central nervous system (2008, background): “The P2X 7 receptor, by regulating IL-1β production, also has a role in the development of neuropathic and inflammatory pai”
• Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages1 (2007, background): “(59) found that local IL-1 levels in the inflamed paws of P2X7R-null mice were markedly reduced despite an absence of global changes in serum IL-1 .”
• Principles of early drug discovery (2011, neutral): “One such example is through use of the P2X7 knockout mouse to confirm a role for this ion channel in the development and maintenance of neuropathic and inflammatory pain (Chessell et al., 2005).”
• Role of the Immune system in chronic pain (2005, background): “Indeed, mice that lack this receptor show an impaired ability to develop neuropathic pai”