Role of the Immune system in chronic pain

By F. Marchand, M. Perretti, S. McMahon. Nature Reviews Neuroscience, 2005

1,115 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/d83120e813a6d0b7781882a5011005e476631b20

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. Arne May
2. Joanna Mika

In Cellular and Molecular Neuroscience

1. R. Ji
2. M. Suter
3. E. Milligan
4. Linda R. Watkins
5. R. Meyer
6. J. Campbell
7. Jürgen Sandkühler
8. Arne May

In Physiology

1. R. Ji
2. Jürgen Sandkühler
3. M. Suter
4. Linda R. Watkins
5. E. Milligan
6. R. Meyer
7. J. Campbell
8. Arne May

Citations in the corpus

• Chronic pain may change the structure of the brain. (2008, methodology): “peripheral, spinal and cerebral nervous system [25,40,50,80].”
• Mechanisms of neuropathic pain. (2006, background): “The immune system appears to play a critical role in neuropathic pain as well (Marchand et al., 2005).”
• Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness. (2008, positive): “It seems that microglia might be responsible for the initiation of neuropathic pain states [22, 46, 58].”
• Models and mechanisms of hyperalgesia and allodynia. (2009, background): “These peripheral mediators trigger the de novo synthesis of proinflammatory cytokines by cells within the central nervous system including the spinal cord, mainly microglia, and astrocytes (324, 562, 565).”
• Biological Effects and Modes of Action of Carvacrol in Animal and Poultry Production and Health - A Review (2015, background): “Marchand et al. (2005), Kaufmann et al. (2011), and Uyanoglu et al. (2011) had contradicting reports regarding including the antioxidant effect of carvacrol in controlling nitric oxide production and lipid peroxidation during hypernociception. anti-obeSity eFFect Obesity is a medical condition in…”
• Pathological and protective roles of glia in chronic pain (2009, background): “For instance, the initiation and maintenance of neuropathic pain in animal models involves neuroexcitatory signals including IL-1β, TNFα and IL-6 (Ref”
• p38 MAPK, microglial signaling, and neuropathic pain (2007, background): “All of these IFMs are implicated in pain facilitation [13-17,44,54,55].”