Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages1

By Yan Qu, L. Franchi, G. Núñez, G. Dubyak. Journal of Immunology, 2007

611 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/383e71abe4ab106639cc50d7a07a7b8ea69c1344

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. A. Dinarello
2. D. Brough
3. G. López‐Castejón
4. Greta Guarda
5. J. Tschopp
6. A. Giuliani
7. A. Sarti
8. S. Falzoni

In Molecular Biology

1. C. A. Dinarello
2. Greta Guarda
3. D. Brough
4. G. López‐Castejón
5. O. Gross
6. Christina J. Thomas
7. Rienk Nieuwland
8. J. Tschopp

In Physiology

1. C. A. Dinarello
2. G. López‐Castejón
3. D. Brough
4. J. Tschopp
5. A. Giuliani
6. A. Sarti
7. S. Falzoni
8. D. Dal Ben

Citations in the corpus

• The P2X7 Receptor in Infection and Inflammation (2017, positive): “P2X7R is a main driver for all these routes (Bianco et al., 2005; Pizzirani et al., 2007; Qu et al., 2007), further emphasizing its fundamental contribution to the release of bioactive IL-1b.”
• Understanding the mechanism of IL-1β secretion (2011, background): “IL-1b can also be secreted in a protected form by being packaged and secreted via exosomes [46].”
• Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth (2012, neutral): “The gap junction intercellular communication (GJIC) participates in molecular communications including the miRNA communication between cells [7, 42] and carbenoxolone inhibits P2X7 receptor-activated microvesicles and exosome release [43].”
• Classification, Functions, and Clinical Relevance of Extracellular Vesicles (2012, background): “Likewise, mouse macrophages, stimulated with ATP, release exosomes with entrapped interleukin-1 , caspase-1 and other components of the inflammasome (Qu et al., 2007).”
• The inflammasome: an integrated view (2011, background): “Several pathways of unconventional protein secretion, including release via secretory lysosomes (145, 146), microvesicle shedding (147), the release of exosomes from multivesicular bodies (148), as well as direct translocation through the cell membrane through transporters or large pores (149, 150) ”
• Anti-inflammatory Agents: Present and Future (2010, positive): “, 2009) from where it is secreted by exocytosis (Qu et al., 2007) (not shown).”