let-7 microRNA functions as a potential growth suppressor in human colon cancer cells.

By Y. Akao, Y. Nakagawa, T. Naoe. Biological and Pharmaceutical Bulletin, 2006

651 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f355c7c8786f43cb40b64b0755f41e0c20d015b1

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Citations in the corpus

MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Let-7 is downregulated in a number of human cancers such as lung, colon, or ovarian cancer, and it serves as a prognostic marker for disease outcome (Takamizawa et al., 2004; Johnson et al., 2005; Akao et al., 2006; Yanaihara et al., 2006; Shell et al., 2007).”
The let-7 microRNA represses cell proliferation pathways in human cells. (2007, result): “This work extends similar analyses in lung and colon cancer cells (4, 28) by showing that multiple different let-7 family members have similar effects on cell proliferation.”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “Indeed, lin28 represses let-7 miRNAs (Viswanathan et al. 2008), which are negative regulators of c-Myc translation (Akao et al. 2006; HH Kim et al. 2009), thus establishing a link between the two reprogramming cocktails (Oct4, Klf4, Sox2, and c-Myc, and Oct4, Sox2, Nanog, and Lin28).”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “In human colon tumors and cancer cell lines, there was a 30% reduction in expression of let-7 miRNAs [48].”
let-7 regulates self renewal and tumorigenicity of breast cancer cells. (2007, background): “Therefore, reduced let-7 may link T-IC and EMT. let-7 genes map to sites with frequent chromosomal instability in cancer (Calin et al., 2004), and let-7 is poorly expressed in lung (Takamizawa et al., 2004) and colon cancer (Akao et al., 2006).”
OncomiRs: the discovery and progress of microRNAs in cancers (2007, background): “Their findings suggested the involvement of let-7 miRNA in the growth of colon cancer cells [40].”
MicroRNAs in development and disease. (2011, background): “K-Ras is also a validated target of let-7, which is also downregulated in 30% of CRC cases (7).”
MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “Functioning as a tumor suppressor, let-7 mediates the suppression of Ras and the cellular processes it modulates [251-254].”
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. (2007, background): “Finally, these results in Burkitt lymphoma and those previously reported for lung (28) and colon (29) cancers validate the apparent regulation of MYC by let-7a and reaffirm its role in the cancer process.”