The let-7 microRNA represses cell proliferation pathways in human cells.

By Charles D. Johnson, A. Esquela-Kerscher, G. Stefani, M. Byrom, Kevin Kelnar, D. Ovcharenko, Mike Wilson, Xiaowei Wang, J. Shelton, Jaclyn Shingara and 3 more. Cancer Research, 2007

1,307 citations recorded by the source corpus.

Subfields: Aging, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5132303de6e429e4fae7a68678fbe5cfea575cd6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. Kenneth S. Kosik
2. Thomas Tuschl
3. Phillip A. Sharp
4. Frank J. Slack

In Cancer Research

1. Phillip A. Sharp
2. Margaret S. Ebert
3. David P. Bartel
4. Frank J. Slack
5. Danish H Sayed
6. M. Abdellatif
7. Thomas Tuschl
8. P. Murphy

In Molecular Biology

1. Phillip A. Sharp
2. David P. Bartel
3. Margaret S. Ebert
4. Thomas Tuschl
5. Frank J. Slack
6. M. Abdellatif
7. Danish H Sayed
8. Pavel Morozov

Citations in the corpus

• MicroRNA and cancer (2012, background): “…et al., 2008) and cell division cycle phosphatases like CDC25A (Sarkar et al., 2010; Yang et al., 2009) are also targeted by miRNAs to inhibit the cell cycle, with reports of these miRNAs being downregulated or lost in tumour cells (Bueno and Malumbres, 2011; Johnson et al., 2007; Yu et al., 2008).”
• Suppression of non-small cell lung tumor development by the let-7 microRNA family (2008, background): “Finally, let-7 family members functionally inhibit the mRNAs of well characterized oncogenes, such as the Ras family (22), HMGA2 (21, 23, 24), c-Myc (11, 25), and cell cycle regulators like CDC25A, CDK6, and Cyclin D2 (20).”
• A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment (2008, background): “, in addition to growing evidence for let-7 as a tumour suppressor and cell-cycle regulato”
• Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases (2019, background): “They demonstrated that, in addition to anti-apoptotic effects, miR21-containing MSC-Exos induced enhanced expression of vascular endothelial growth factor (VEGF) and promoted neovascularization in ischemic hearts, significantly improving cardiac function after AMI [101].”
• MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. (2008, result): “These data are also consistent with findings in glioblastomas that significant effects of miRNAs occur indirectly rather than by direct targeting (24, 43).”
• MicroRNAs in human cancer. (2013, background): “Expression of let-7 is downregulated in non-small cell lung cancer patients [ 192 ] and is associated with poor prognosis [ 125, 193 ] , whereas a miRNA signature was identi fi ed to be associated with prognosis in CLL [ 188 ] .”
• Non-coding RNAs as regulators of embryogenesis (2011, background): “let-7 represses several key pathways that are crucial for ES cell identity, including genes that promote cell cycle progressio”
• MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “Let-7 in cancer cell lines has also been shown to alter cell-cycle progression through its actions on multiple genes involved in the cell cycle and cell division, suggesting that let-7 acts as a tumor suppressor by regulating several cell-proliferation pathways [51].”
• MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Overexpression of let-7 inhibits cancer growth (Takamizawa et al., 2004; Akao et al., 2006; Johnson et al., 2007) and its inhibition promotes growth (Kumar et al., 2007).”