The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters.

By P. Wender, D. Mitchell, Kanaka Pattabiraman, E. Pelkey, L. Steinman, J. Rothbard. Proceedings of the National Academy of Sciences of the United States of America, 2000

1,543 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f312cafe1f602810d79b556f704cde22600a81fe

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In Molecular Biology

1. L. Rajendran
2. F. Heitz
3. May C. Morris
4. R. Gabathuler
5. Cherine Bechara
6. H. Knölker
7. G. Divita
8. S. Sagan

Citations in the corpus

• Cell‐penetrating peptides: 20 years later, where do we stand? (2013, background): “A closer look led to the finding that arginine residues were more effective in terms of internalization than lysines, and that replacing lysine residues with arginine increased the rates of the uptake [14,91].”
• Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics (2009, positive): “…that polyarginine sequences (Arg8) were sufficient to drive molecules into cells and proposed that their uptake mechanism involves a bidentate hydrogen-bonding interaction between guanidinium group of arginine residues and phosphate group in the membrane (Wender et al., 2000; Futaki et al., 2001).”
• Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent. (2009, methodology): “In this study, we design a short amphiphilic peptide (CG 3 R 6 TAT), which contains a hydrophilic block of cell-penetrating peptide TAT and six arginine residues (R 6 or Arg 6 ) for adding more cationic charges to improve membrane translocatio”
• Cell-Penetrating Peptides: From Basic Research to Clinics. (2017, background): “Cationic Class The cationic class comprises peptides with highly positive net charges at physiological pH that primarily originate from the basic short strands of arginines and lysines.”
• Subcellular targeting strategies for drug design and delivery (2010, background): “It is not clear how these peptides (and their conjugates of diverse chemical nature) cross the membrane at neutral pH, although interaction of cationic peptides with membrane phospholipids is thought to trigger a conformational change that allows their insertion into the membran”
• CNS Delivery Via Adsorptive Transcytosis (2008, background): “Vector stability may also be enhanced by using peptide mimics such as beta-peptides (86 )o r peptoides ( 56 ).”
• Cellular uptake of arginine-rich peptides: roles for macropinocytosis and actin rearrangement. (2004, background): “Until now, various carrier peptides were reported to have an ability to co-internalize exogenous molecules into cells [1–5,8–13].”
• Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. (2010, background): “Poly-arginines (9 mer of L-Arg, R9) showed a very efficient cellular uptake 20× superior than TAT4957 and D-Arg oligomers (r9)N100 fold superior (Wender et al., 2000).”