Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system

By S. Pukatzki, Amy T. Ma, D. Sturtevant, Bryan Krastins, D. Sarracino, W. Nelson, J. Heidelberg, J. Mekalanos. Proceedings of the National Academy of Sciences of the United States of America, 2006

1,163 citations recorded by the source corpus.

Subfields: Endocrinology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/f2aae729010fd5dd9a8610605c8dfbcc9a3c90cb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. Rebekah M. Martin
2. Jung Hun Lee
3. Chang-Ro Lee
4. B. Jeong
5. S. Lee
6. M. Bachman
7. Kwang Seung Park

In Molecular Medicine

1. Rebekah M. Martin
2. Jung Hun Lee
3. Chang-Ro Lee
4. B. Jeong
5. S. Lee
6. M. Bachman
7. Kwang Seung Park

Citations in the corpus

• Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum (2007, background): “, 2003), and another resembling a hemolysin coregulated protein (hcp) associated with virulence in Vibrio (Pukatzki et al., 2006), were considered potentially disease relevant.”
• The Legionella pneumophila replication vacuole: making a cozy niche inside host cells (2008, background): “It has been argued that these orthologues are components of the recently discovered type VI secretion system (T6SS”
• Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options (2017, background): “The proposed A. baumannii virulence factors are summarized in Table 1.”
• Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae (2018, background): “The type VI secretion system (T6SS), first identified in V. cholerae (Pukatzki et al., 2006), is a syringe-like apparatus anchored within the bacterial cell membrane that serves to inject various effector molecules and toxins into other cells (Journet and Cascales, 2016).”
• Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin (2009, background): “Interestingly, the conserved Hcp and VgrG proteins are both secreted and required for the function of the T6SS machine (2, 4, 12, 13).”