The Legionella pneumophila replication vacuole: making a cozy niche inside host cells
By R. Isberg, T. O’Connor, M. Heidtman. Nature Reviews Microbiology, 2008
681 citations recorded by the source corpus.
The pathogenesis of Legionella pneumophila is derived from its growth within lung macrophages after aerosols are inhaled from contaminated water sources. Interest in this bacterium stems from its ability to manipulate host cell vesicular-trafficking pathways and establish a membrane-bound replication vacuole, making it a model for intravacuolar pathogens. Establishment of the replication compartment requires a specialized translocation system that transports a large cadre of protein substrates across the vacuolar membrane. These substrates regulate vesicle traffic and survival pathways in the host cell. This Review focuses on the strategies that L. pneumophila uses to establish intracellular growth and evaluates why this microorganism has accumulated an unprecedented number of translocated substrates that are targeted at host cells.
Subfields: Endocrinology, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/6bca782adfbe4a78ccf7576bf891cfb8c1d9c3b7
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Citations in the corpus
- Bacterial Secretion Systems – An overview (2016, background): “pneumophila uses its T4SS to translocate more than 200 effector proteins into the host cell, where they play important roles in remodeling the host cell architecture to create a vacuole suitable for bacterial replication (83).”
- Antimicrobial mechanisms of phagocytes and bacterial evasion strategies (2009, background): “More than 80 different T4SS effectors have been implicate”