Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options
By Chang-Ro Lee, Jung Hun Lee, Moonhee Park, Kwang Seung Park, I. K. Bae, Young Bae Kim, C. Cha, B. Jeong, S. Lee. Frontiers in Cellular and Infection Microbiology, 2017
880 citations recorded by the source corpus.
Acinetobacter baumannii is undoubtedly one of the most successful pathogens responsible for hospital-acquired nosocomial infections in the modern healthcare system. Due to the prevalence of infections and outbreaks caused by multi-drug resistant A. baumannii, few antibiotics are effective for treating infections caused by this pathogen. To overcome this problem, knowledge of the pathogenesis and antibiotic resistance mechanisms of A. baumannii is important. In this review, we summarize current studies on the virulence factors that contribute to A. baumannii pathogenesis, including porins, capsular polysaccharides, lipopolysaccharides, phospholipases, outer membrane vesicles, metal acquisition systems, and protein secretion systems. Mechanisms of antibiotic resistance of this organism, including acquirement of β-lactamases, up-regulation of multidrug efflux pumps, modification of aminoglycosides, permeability defects, and alteration of target sites, are also discussed. Lastly, novel prospective treatment options for infections caused by multi-drug resistant A. baumannii are summarized.
Subfields: Endocrinology, Molecular Biology, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/09cad046bd579c138c2541bd8395a0dee2f1b733
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In Endocrinology
In Molecular Biology
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In Molecular Medicine
Citations in the corpus
- Bacterial Antibiotic Resistance: The Most Critical Pathogens (2021, background): “baumannii may acquire resistance to colistin, a polypeptide antibacterial agent that targets LPS, as a result of mutation of the genes involved in LPS biosynthesis [45,46]; (5) the modification of the antibiotic target [47].”
- A Deep Learning Approach to Antibiotic Discovery. (2020, methodology): “Of note, the World Health Organization has designated A. baumannii as one of the highest priority pathogens against which new antibiotics are urgently required (Lee et al., 2017; Perez et al., 2007).”
- A deep learning approach to antibiotic discovery (2020, background): “Of note, the World Health Organization has designated A. baumannii as one of the highest priority pathogens against which new antibiotics are urgently required (Lee et al., 2017; Perez et al., 2007).”
- Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It (2020, background): “baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE) organisms, as declared by the WHO that can escape the effect of antibacterial drugs [13].”