Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin
By P. Leiman, M. Basler, U. Ramagopal, J. Bonanno, J. M. Sauder, S. Pukatzki, Stephen K. Burley, S. Almo, J. Mekalanos. Proceedings of the National Academy of Sciences of the United States of America, 2009
650 citations recorded by the source corpus.
Subfields: Ecology, Endocrinology, Genetics
View Paper: https://www.semanticscholar.org/paper/bea54b737315945dfadd15b38fcb07795701c0dc
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Ecology
In Genetics
- Andriy Kryshtafovych
- Krzysztof Fidelis
- Torsten Schwede
- Bohdan Monastyrskyy
- Pierre Baldi
- Ken Nagata
- Pietro Di Lena
Citations in the corpus
- Type VI secretion requires a dynamic contractile phage tail-like structure (2012, positive): “Leiman et al.(10) noted that VipA/VipB tubules visually resemble T4 contracted tail sheath and were the first to propose that a sheath-like structure might power T6SS translocation by a phage tail-like contraction mechanism.”
- A Phage Tail-Derived Element with Wide Distribution among Both Prokaryotic Domains: A Comparative Genomic and Phylogenetic Study (2014, background): “Such roles have been attributed to phage-derived elements identified in several Gram-negative species: The type VI secretion system (T6SS), the R- and F-type pyocins, and the newly discovered Serratia entomophila antifeeding prophage (Afp), and the Photorhabdus luminescens virulence cassette (PVC).”
- Three-dimensional Structure of the Toxin-delivery Particle Antifeeding Prophage of Serratia entomophila * (2013, background): “The head of this assembly is homologous to VgrG, a T6SS protein (16) with some amino acid sequence similarity toAfp8 (4).”
- Contractile injection systems of bacteriophages and related systems (2018, background): “Several fusions occur in other systems, most notably of the hub and the spike in T6SS VgrG (Pukatzki et al., 2007; Leiman et al., 2009) or of the spike and spike tip in phage P2 gpV and R-type pyocin PA0616 (Browning et al., 2012).”
- A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria (2010, background): “Recent X-ray crystallographic insights into Hcp and Vgr family proteins show that they are similar to bacteriophage tube and tailspike proteins, respectively (Leiman et al., 2009; Pell et al., 2009).”
- Target highlights in CASP13: experimental target structures through the eyes of their authors (2019, background): “tails, the Type VI secretion system (T6SS), R-pyocins, and tailocins are multiprotein injection devices sharing a seringe-like architecture.(82-84)”