Mechanism of homologous recombination: mediators and helicases take on regulatory functions

By P. Sung, H. Klein. Nature reviews. Molecular cell biology, 2006

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Overexpressed of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability (2010, background): “The proteins directly involved in the displacement of RPA are named ‘recombination mediators’ (Table 1) (10,11) (here sometimes referred to as just ‘mediators’).”
Maintaining genome stability at the replication fork (2010, background): “These proteins do not affect FANCD2 ubiquitylation, but contribute to HR repai”
Regulation of DNA repair throughout the cell cycle (2008, background): “Studies in budding yeast have established that HR is carried out by the products of the conserved RAD52 epistasis group of gene”
How the fanconi anemia pathway guards the genome. (2009, background): “FANCD1, better known as BRCA2, is a recombination mediator that facilitates the formation of Rad51 nucleofilaments (134, 161).”