Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia.

By G. Silvestri, D. Sodora, R. Koup, M. Paiardini, S. O’Neil, H. McClure, S. Staprans, M. Feinberg. Immunity, 2003

698 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/f2446b848be1058111902cd64b89f6d79ad0f6df

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Yong‐Zhen Zhang
2. Edward C. Holmes

In Immunology

1. Steven G. Deeks
2. Daniel C. Douek
3. V. Appay
4. D. Sauce
5. B. Blazar
6. J. McCune
7. A. McMichael
8. Mario Roederer

In Virology

1. Daniel C. Douek
2. Steven G. Deeks
3. V. Appay
4. D. Sauce
5. Yong‐Zhen Zhang
6. Edward C. Holmes

Citations in the corpus

• Microbial translocation is a cause of systemic immune activation in chronic HIV infection (2006, background): “Nonpathogenic natural SIV infection Chronic SIV infection in its natural primate hosts, such as sooty mangabeys, is typically nonpathogenic, even in the context of chronic high-level viremia, and is characterized by low levels of immune activatio”
• The Evolution and Emergence of RNA Viruses (2009, background): “Indeed, SIV in its natural hosts is not associated with a decline in the number of CD4 T cells despite long-term infection and high levels of viraemia, and does not seem to generate an overly strong immune response (Broussard et al. 2001; Silvestri et al. 2003).”
• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “In contrast, SIV-infected sooty mangabeys and African green monkeys, the natural hosts of SIV, which do not develop any immunodeficiency, exhibit minimal T cell activation despite evident viral replication [25].”
• The immune response during acute HIV-1 infection: clues for vaccine development (2009, background): “This is despite high levels of virus replication and acute CD4 + T cell depletio”
• Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. (2008, background): “The observation that T cell activation distinguishes pathogenic from nonpathogenic SIV infection further suggests that T cell activation is a significant mediator of immunodeficiency in HIV infection [28].”