Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency

By Baoyang Hu, J. Weick, Junying Yu, Li-Xiang Ma, Xiaoqing Zhang, James A. Thomson, Su-Chun Zhang. 2010

1,045 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

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Citations in the corpus

Induced pluripotent stem cells: past, present, and future. (2012, neutral): “Hu et al. (2010) performed in vitro directed neural differentiation of five human ESC clones and 12 iPSCs clones.”
Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration (2020, background): “genomic stability and differencing capability in iPSC lines [79].”
Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines (2011, neutral): “For example, it has been reported that human iPS cells collectively deviate from ES cells in the expression of hundreds of genes (Chin et al., 2009), in their genome-wide DNA methylation patterns (Doi et al., 2009), and in their neural differentiation properties (Hu et al., 2010).”
Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA (2010, background): “The risk of mutagenesis is not the only safety concern holding back clinical application of induced pluripotency, and it has become increasingly apparent that all iPSCs are not created equal with respect to epigenetic landscape and developmental plasticity (Hu et al., 2010; Miura et al., 2009).”
Incomplete DNA methylation underlies a transcriptional memory of the somatic cell in human iPS cells (2011, neutral): “Human iPS cells have been suggested to be less efficient than ES cells in targeted differentiation to neural and blood lineage”
The promise of induced pluripotent stem cells in research and therapy (2012, background): “Some mouse iPS cells showed lower efficiencies of teratoma formation than mouse ES cells, whereas some human iPS cells showed less propensity to differentiate along haematopoietic, neuroepithelial and neuronal lineages than human ES cell”
Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. (2011, neutral): “…recent works have addressed the differences between the two PSC types (Chin et al., 2009; Doi et al., 2009; Feng et al., 2010; Ghosh et al., 2010; Hu et al., 2010; Kim et al., 2010; Lister et al., 2011; Marchetto et al., 2009; May-shar et al., 2010; Ohi et al., 2011; Pick et al., 2009; Polo et…”
Origin and differentiation of microglia (2013, result): “In contrast to the numerous protocols for efficient generation of astrocytes and neurons from pluripotent stem cells (Lee et al., 2000; Zhang et al., 2001; Hu et al., 2010), there is little literature reporting methods for obtaining phenotypicallycorrect microglia from the same cell sources.”
Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, background): “Consequently, in addition to producing a neuronal subtype, hPSCs can potentially recapitulate the developmental stages of the neuron of interest (Hu et al., 2010; Shi et al., 2012b; Nicholas et al., 2013) and provide insights into the pathogenesis of neurodevelopmental diseases where deficits origin”
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells (2011, neutral): “5 includes all the DMRs larger than 1 Mb (17) and a range of smaller ones.”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “For example, a reduced and more variable neuronal potential has been described for a number of human iPSC lines, regardless of whether they carried reprogramming transgenes in their genome or not (Hu et al. 2010).”