Essential role for nuclear PTEN in maintaining chromosomal integrity.

By W. Shen, A. Balajee, Jianli Wang, Hong Wu, C. Eng, P. Pandolfi, Yuxin Yin. Cell, 2007

1,008 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f1c5f82df67a37ee92798a5cfcf326377e46e82f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. T. Balla
2. C. Lord
3. P. Pandolfi
4. Arkaitz Carracedo
5. Alan Ashworth
6. L. Salmena
7. R. Brough
8. T. Waldman

Citations in the corpus

• Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “Differentiated and quiescent cells harbor high levels of nuclear PTEN, which appears to fulfill important roles in the maintenance of genomic integrity, through centromere stabilization and promotion of DNA repair (Shen et al. 2007).”
• Phosphoinositides: tiny lipids with giant impact on cell regulation. (2013, background): “Clearly, there is more to PTEN function than PtdIns(3,4,5)P3 signaling, and its link to nuclear proteins, chromosomal instability, DNA repair, and kinetochore assembly (1394) suggests a complexity that has yet to be fully understood.”
• Tenets of PTEN tumor suppression. (2008, background): “More recently, as discussed above, PTEN loss has been shown to have detrimental effects on genomic stability (Shen et al., 2007).”
• Cancer genomics: from discovery science to personalized medicine (2011, background): “This hypothesis was based on a previously unidentified role for PTEN suggested by the observation that mouse embryonic PTEN -/- cells show genomic instability ascribed to defects in RAD51-mediated DNA double-strand break repai”
• Maximizing mouse cancer models (2007, background): “In light of this, it will be interesting to determine whether the recently discovered role for nuclear PTEN in maintaining genomic integrit”
• PTEN loss in the continuum of common cancers, rare syndromes and mouse models (2011, positive): “The binding of PTEN to centromere protein C1 (CENP-C1) is required for centrosome stability, and its nuclear localization is required for DNA double-strand break (DSB) repair that is mediated by DNA repair protein RAD51 (Ref”
• Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Analysis of senescence markers in human cancer biopsies from patients previously exposed to neoadjuvant chemotherapy confirmed the occurrence of TIS and its association to treatment outcome (12, 293, 316, 321).”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Pten deficiency in mice causes increases in cell proliferation, apoptotic resistance, stem-cell renewal/maintenance, centromeric instability, and DNA double-strand breaks (Groszer et al., 2001; Kimura et al., 2003; Wang et al., 2006; He et al., 2007; Shen et al., 2007), which can enhance susceptibil”
• Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors (2009, positive): “A new functional role for PTEN was recently suggested by the observation that mouse embryonic Pten (cid:1) / (cid:1) cells exhibit genomic instability, a phenotype ascribed to either defects in RAD51-mediated DNA double strand break repair (DSBR) (Shen et al, 2007) or defects in cell cycle checkpoin”