Comparative genomics, minimal gene-sets and the last universal common ancestor

By Eugene V. Koonin. Nature Reviews Microbiology, 2003

647 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f10befb54316a45bb890cd4ae9e1dc5ad8358d07

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Toni Gabaldón
2. Artem S. Novozhilov
3. Eugene V. Koonin
4. Claudia Alvarez-Carreño
5. Andrés Moya
6. Anton I. Petrov
7. Francisco J. Silva
8. Loren Dean Williams

In Plant Science

1. Toni Gabaldón
2. Artem S. Novozhilov
3. Andrés Moya
4. Francisco J. Silva
5. Eugene V. Koonin

Citations in the corpus

• The Logic of Chance: The Nature and Origin of Biological Evolution (2011, background): “These findings have been conceptualized in the notion of non-orthologous gene displacement (NOGD), an evolutionary scenario under which unrelated or distantly related genes (not orthologs) become responsible for the same essential function in different organisms (Koonin, 2003).”
• Origin and evolution of the genetic code: the universal enigma (2008, background): “complete set of aminoacyl-tRNA synthetases among the extant cellular life forms (117, 118) strongly suggests that the main features of the translation system were fixed at a pre-LUCA”
• Fold Evolution before LUCA: Common Ancestry of SH3 Domains and OB Domains (2021, background): “The translation system dominates the Universal Gene Set of Life (Harris et al. 2003; Koonin 2003; Charlebois and Doolittle 2004), which is the set of orthologous genes that are universal and are assumed to have been present at or before the last universal common ancestor (LUCA).”
• Determination of the Core of a Minimal Bacterial Gene Set (2004, background): “…more analyzed organisms The notion of a minimal cell cannot be sharply defined, since different essential functions can be defined depending on the environmental conditions, and numerous versions of minimal gene sets can be conceived to fulfill such functions even for the same set of conditions (49 .”
• Evolution of proteins and proteomes: a phylogenetics approach (2005, background): “Recent estimates, that correct for horizontal gene transfers and non-orthologous gene displacements, suggest a simple last universal common ancestor with only 500-600 proteins (Koonin 2003).”
• Orthologs, Paralogs, and Evolutionary Genomics 1 (2005, background): “, recruitment of non-orthologous genes for the equivalent, essential functions in different organisms (47, 52).”