Insulin Resistance, Hyperglycemia, and Atherosclerosis
By K. Bornfeldt, I. Tabas. Cell Metabolism, 2011
873 citations recorded by the source corpus.
Progress in preventing atherosclerotic coronary artery disease (CAD) has been stalled by the epidemic of type 2 diabetes. Further advances in this area demand a thorough understanding of how two major features of type 2 diabetes, insulin resistance and hyperglycemia, impact atherosclerosis. Insulin resistance is associated with systemic CAD risk factors, but increasing evidence suggests that defective insulin signaling in atherosclerotic lesional cells also plays an important role. The role of hyperglycemia in CAD associated with type 2 diabetes is less clear. Understanding the mechanisms whereby type 2 diabetes exacerbates CAD offers hope for new therapeutic strategies to prevent and treat atherosclerotic vascular disease.
Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Genetics
View Paper: https://www.semanticscholar.org/paper/937cd80ab0d7b1810791bfb465bcded08a20bf0e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology, Diabetes and Metabolism
In Epidemiology
- A. Lichtman
- A. Goldfine
- W. Hiatt
- Cecilia C. Low Wang
- Connie N. Hess
- Linda Partridge
- T. Niccoli
- I. Tabas
In Genetics
Citations in the corpus
- Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes – Mechanisms, Management, and Clinical Considerations (2016, positive): “Impairment of insulin signaling at multiple points in the insulin signaling pathway in endothelial cells, VSMC, 80 and macrophages(22,23,58) promotes development and progression of atherosclerosis, as does the proinflammatory state induced in insulin resistance (Figure 2).(22,23,81) Both systemic an”
- Association between insulin resistance and the development of cardiovascular disease (2018, background): “It also induces apoptosis and impairs NO release, leading to endothelial dysfunction [7, 131].”
- Ageing as a risk factor for disease. (2012, background): “Strikingly, centenarians maintain high insulin sensitivity [28], whereas genetic variants associated with decreased insulin signalling are associated with insulin resistance and diabetes [31], suggesting systemic IIS pathway activation itself confers protection from cardiovascular disease in the abs”
- Monocyte-Macrophages and T Cells in Atherosclerosis (2017, positive): “Insulin resistance is a potent risk factor for atherosclerotic heart diseasebecause of its links to dyslipidemia and inflammation and because of the effects of high insulin and glucose on atherosclerotic lesional cells (Razani et al., 2008; Bornfeldt and Tabas, 2011).”