The Randle cycle revisited: a new head for an old hat.

By L. Hue, H. Taegtmeyer. American Journal of Physiology. Endocrinology and Metabolism, 2009

727 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Pathological Ventricular Remodeling: Mechanisms: Part 1 of 2 (2013, background): “bolic demands of the heart are met by metabolism of fatty acids and glucose and, to a lesser extent, lactate and ketone bodies.(134)”
Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity (2018, background): “In this regard, activation of lipolysis provides FFAs as the preferred fuel source leading to ketogenesis during fasting whereas inhibition of glucose oxidation contributes to a glucose-sparing effect that is an essential survival mechanism during times of starvation.(67) In the fed state or during ”
Lipolysis – A highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores (2011, background): “This mechanism adapts substrate utilization to substrate availability in coordination with hormones controlling energy metabolism [160].”
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “As conditions such as cardiac workload, oxygen supply and nutritional supply are altered, the heart is able to adapt and rely on varying proportions of substrates as a source of ATP to ensure that a constant supply of energy can be generated (Hue and Taegtmeyer 2009).”