Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.

By Y. Mizutani, A. Kihara, Y. Igarashi. 2005

391 citations recorded by the source corpus.

Subfields: Biochemistry, Cell Biology, Cellular and Molecular Neuroscience

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Citations in the corpus

Mammalian Ceramide Synthases (2010, background): “Moreover, it is the only CerS that does not contain a Hox-like domain (18, 23).”
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas (2007, background): “The mammalian homologues of yeast LAG1 were later identified in human, Caenorhabditis elegans (19), and mouse (17), and recent independent studies have shown specific functions of mouse LASS1, LASS5, and LASS6 in the specific generation of C18-, C16- and C14/C16ceramides, respectively (17, 30, 31).”
Potentiation of cannabinoid-induced cytotoxicity in Mantle Cell Lymphoma through modulation of ceramide metabolism (2009, background): “CerS6 is a major CerS that is expressed at high levels in a variety of tissues (11) and is associated with”
Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2 (2008, neutral): “However, although CerS5 expression was detectable in all brain areas including white matter, CerS5 has a strict substrate preference for short to long chain fatty acids (C12–C18) in vivo and in vitro, in both, mammalian cells and yeast (Mizutani et al. 2005; Cerantola et al. 2007).”
Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue. (2009, background): “Leptin regulates the expression of enzymes involved in ceramide metabolism Because in mammalian tissues ceramides are mainly produced by de novo synthesis, we analyzed the expression pattern and the enzymatic activity of SPT, the rate-limiting enzyme in this pathway, as well as expression of the thr”
Multiple New Loci Associated with Kidney Function and Chronic Kidney Disease: The CKDGen consortium (2010, neutral): “LASS2 has been implicated in the synthesis of specific ceramides.(48) Ceramides and their product sphingolipids are important in genetic diseases of the kidney,(49) and have a role in aging mechanisms.”
Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “…factor 1 (UOG1) (Lee, 1991; Venkataraman et al., 2002), demonstrated that it specifically regulates the synthesis of C18-ceramide with a high degree of fatty-acid chain length specificity (Venkataraman et al., 2002; Riebeling et al., 2003; Mizutani et al., 2005; Kageyama-Yahara and Riezman, 2006).”
Antiapoptotic roles of ceramide‐synthase‐6‐generated C16‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways (2010, background): “To determine the roles of dh-C18and dh-C16-ceramides generated by CerS1 and CerS6, respectively (9, 31), in the regulation of cell death, the expression of CerS1 and CerS6 was down-regulated using siRNAs.”
CERAMIDE SYNTHASE 1 IS REGULATED BY PROTEASOMAL MEDIATED TURNOVER (2009, background): “This is interesting because there are mixed reports regarding CerS1 expression in lung cells [8,11].”
An overview of sphingolipid metabolism: from synthesis to breakdown (2010, background): “Cers5 and CerS6 both prefer palmitoyl CoA as substrates and generate predominantly C16-ceramide species [22], [23].”