Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas

By C. Senkal, S. Ponnusamy, M. Rossi, Jacek Bialewski, D. Sinha, J. Jiang, S. Jazwinski, Yusuf A. Hannun, B. Ogretmen. 2007

173 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

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Mammalian Ceramide Synthases (2010, background): “In a study examining the sensitivity of cells to chemotherapeutic drugs, siRNA to CerS1 prevented gemcitabine/doxorubicin-induced caspase 9 activation, whereas CerS4 or CerS5 siRNA did not have any effect (43).”
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cells (2009, unknown): “Exogenous CerS6 localizes primarily to the perinuclear region Ceramide synthases have been identified as proteins that localize to the endoplasmic reticulum (Venkataraman et al., 2002; Riebeling et al., 2003; Mizutani et al., 2005; Kitatani et al., 2006; Senkal et al., 2007).”
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. (2007, background): “Further experiments showed that overexpression of the mammalian homologue of the yeast longevity assurance gene 1 (LASS1), also referred to as ceramide synthase1 (CerS1), which is known to selectively generate C18-ceramide, resulted in the inhibition of HNSCC cell growth, and enhanced chemotherapy-i”
Antiapoptotic roles of ceramide‐synthase‐6‐generated C16‐ceramide via selective regulation of the ATF6/ CHOP arm of ER‐stress‐response pathways (2010, methodology): “Our previous studies (3, 27, 28) have suggested that de novo-generated C18- and C16-ceramides play distinct roles in the regulation of cell death and/or the pathogenesis of HNSCCs.”
CERAMIDE SYNTHASE 1 IS REGULATED BY PROTEASOMAL MEDIATED TURNOVER (2009, background): “It should be noted that CerS1 is also expressed in head and neck carcinoma cells [18,19].”
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing (2009, unknown): “The CerS enzymes are important regulators of ceramide homeostasis, and CerS1 is central to regulating C18 ceramide, which has been shown to be important in cancer and the response to chemotherapeutic drugs [1,15,16,18].”
Roles of bioactive sphingolipids in cancer biology and therapeutics. (2008, background): “More importantly, these data were also supported by studies which demonstrated that defects in the LASS1-dependent generation of C18-ceramide play important roles in HNSCC growth (Koybasi et al., 2004), and/or response to therapy in human HNSCC cells in situ and in vivo (Senkal et al., 2007).”