NF-?B regulation in the immune system

By Qiutang Li, Inder M. Verma. 2002

2,571 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f04913ff134dabc7b022085fa9bba8ba0bd52e75

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Citations in the corpus

To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis (2003, background): “They are best known for their pivotal roles in immune, inflammatory and acute phase responses, but they also play important roles in cell growth, apoptosis and oncogenesis (reviewed in Silverman and Maniatis, 2001; Karin and Lin, 2002; Li and Verma, 2002).”
Inflammation, a Key Event in Cancer Development (2006, background): “Once the inflammation-associated tumors are formed, iNOS expression may be persistently stimulated by cytokines and NF-nB that are prevalent within the tumor inflammatory microenvironment (130).”
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. (2003, background): “Correspondingly, various target genes of AP-1 and NF- B were identified as proliferative and apoptotic cellular responses (8, 14, 15, 28, 30).”
S100A8 and S100A9 in inflammation and cancer. (2006, background): “immune responses [21], recent studies demonstrated that NFkB regulates cell proliferation, survival, and cell migration, and is constitutively active in different types of cancer [22].”
Essential role of RelA Ser311 phosphorylation by ζPKC in NF‐κB transcriptional activation (2003, background): “…(NF-kB) complexes are essential for the control of a large variety of cellular functions including the synthesis of in¯ammatory cytokines and cell survival, both central to the control of the immune response and in tumor transformation (Karin et al., 2002; Li and Verma, 2002; Moscat et al., 2003).”
Targeting phosphoinositide 3-kinase: moving towards therapy. (2008, background): “As a consequence, the latter translocates to the nucleus and activates transcription of anti-apoptotic proteins such as Bcl-2 and Bcl-XL [65,66].”