Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

By Kazuki Kato, Hiroki Omura, R. Ishitani, O. Nureki. Annual Review of Biochemistry, 2017

834 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/f01c6a3b1ebe63caf6cc74ad91f6a8969187e0f2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Zhijian J. Chen
2. Tuo Li
3. A. Ablasser
4. P. Jat
5. R. Kumari
6. Qi Chen
7. Junyao Ren
8. Shizuo Akira

In Infectious Diseases

1. Tuo Li
2. A. Ablasser
3. P. Jat
4. R. Kumari
5. Zhijian J. Chen

Citations in the corpus

• Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “TBK1 phosphorylates Frontiers in Cell and Developmental Biology | www.frontiersin.org 10 March 2021 | Volume 9 | Article 645593 the transcription factor IRF3, leading to its translocation from cytosol to the nucleus where it activates the transcription of type-I interferons such as IFN-β (Sun et al.”
• cGAS is essential for cellular senescence (2017, background): “cGMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that is activated by binding to double-stranded DNA, including microbial and self-DNA (22, 23).”
• cGAS in action: Expanding roles in immunity and inflammation (2019, background): “Upon cGAMP binding, the CTD undergoes extensive conformational alterations, including the adoption of a more closed conformation by the V-shaped dimer and the formation of a “lid” covering the cGAMP binding site (19).”
• The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “The molecular details of the cGAS–STI NG pathway and its pivotal roles in eliciting effective immunity against various microbial pathogens have been extensively reviewed elsewhere (Xiao and Fitzgerald, 2013; Cai et al., 2014; Wu and Chen, 2014; Chen et al., 2016b; Ma and Damania, 2016; Tao et al., 2”
• Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “Although CDN synthesis has been considered a unique feature of bacterial species, the recently identified mammalian enzyme cGAS can synthesize the CDN cyclic di-GMP/AMP (cGAMP) (239, 240).”