cGAS is essential for cellular senescence

By Hui Yang, Hanze Wang, Junyao Ren, Qi Chen, Zhijian J. Chen. Proceedings of the National Academy of Sciences of the United States of America, 2017

900 citations recorded by the source corpus.

Subfields: Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/53932ad7980bdead587fef743782fa6dea315c0c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Tuo Li
2. Zhijian J. Chen
3. A. Ablasser
4. Alejandra Hernandez-Segura
5. Jesús Gil
6. J. Nehme
7. M. Demaria
8. Shizuo Akira

In Physiology

1. Jesús Gil
2. Alejandra Hernandez-Segura
3. J. Nehme
4. Zhijian J. Chen
5. Tuo Li
6. A. Alimonti
7. J. Kohli
8. E. Zagato

Citations in the corpus

• The senescence-associated secretory phenotype and its physiological and pathological implications (2024, neutral): “In addition, the cGAS–STING pathway, which is essential for cellular senescence 95 , also directly drives chronic inflammation and immune dysfunction during ageing.”
• Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “cGAS is a DNA sensor that, through the adaptor protein STING, triggers cellular senescence and the transcription of genes that control the SASPs (104, 139, 353).”
• Senescence and the SASP: many therapeutic avenues (2020, background): “The cGAS/STING pathway is considered a key regulator of SASP induction (Dou et al. 2017; Glück et al. 2017; Yang et al. 2017).”
• cGAS in action: Expanding roles in immunity and inflammation (2019, background): “After periods of progressive stress, senescent cells remodel their nuclear envelope, and this is accompanied with the repetitive release of cytosolic chromatin fragments, which present potent triggers of inflammation via cGAS (47, 48, 68).”
• The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer (2018, background): “Recent research has provided strong evidence that cGAS also has an essential role in promoting cellular senescence (Dou et al., 2017; Glück et al., 2017; Yang et al., 2017).”
• Hallmarks of Cellular Senescence. (2018, positive): “The major trigger for NF-kB activation is the DDR, but more recently the cGAS/STING pathway (see the section ‘Nuclear Changes’) has also been implicated [54,55].”