Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

By G. Nguyen, F. Delarue, Céline Burcklé, L. Bouzhir, T. Giller, J. Sraer. Journal of Clinical Investigation, 2002

1,449 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/efd0284ce22cb701d9b4f2456394488d5d1ccc53

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In Cardiology and Cardiovascular Medicine

1. J. Forbes
2. S. Atlas
3. M. Cooper
4. K. Griendling
5. P. Mehta
6. S. Dikalov

In Genetics

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2. K. Griendling
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In Molecular Biology

1. J. Forbes
2. S. Atlas
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5. P. Mehta

Citations in the corpus

• Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. (2007, background): “Nguyen and colleagues (130) have recently shown that activation of the renin receptor also increases the conversion of angiotensinogen to ANG I, with resultant activation of mitogen-activated protein kinases (MAPKs); interestingly, a high level of renin receptor mRNA is present in the heart and reni”
• The Renin-Angiotensin Aldosterone System: Pathophysiological Role and Pharmacologic Inhibition (2007, background): “For example, Ang-(1-7), a heptapeptide fragment of Ang II, can be formed from Ang I or Ang II by the actions of several endopeptidases or from Ang II by the action of carboxypeptidases, including one with significant structural homology to ACE (which has been termed “ACE 2”).”
• Renin‐angiotensin system revisited (2008, background): “Renin receptors were identified and cloned rather recently and shown to be functional [51] .”
• Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment (2021, background): “Renal cells are able to synthesize renin, renin receptors, angiotensin receptors [39], and Ang-II locally independent of systemic RAS [40], so that the kidneys are able to maintain high intrarenal levels of Ang-II.”
• The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease (2007, background): “However, the (pro)renin receptor may also initiate intracellular signaling to activate extracellular signal-regulated kinases 1/2 (Nguyen et al., 2002) and p38 mitogen-activated protein kinase (Saris et al.”
• Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. (2004, background): “Adding a new level of complexity to the RAS, recently a renin receptor has been reported in the heart, kidney, brain, placenta and liver, which may function to increase the catalytic activity of renin [13], and an ACE homologue, ACE2, has been isolated [14,15] and found to play an essential role in ”
• Mechanisms of diabetic complications. (2013, background): “The (pro) renin receptor is widely expressed at sites of diabetic complications including the kidney (422) where blockade has shown renoprotection in animal models (260).”