Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure.

By Y. Li, Guilin Qiao, M. Uskoković, Wei Xiang, Wei Zheng, J. Kong. Journal of Steroid Biochemistry and Molecular Biology, 2004

645 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/2ea04811de23cfc3e47b518fb12d90ff997087a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. M. F. Holick
2. M. Wacker
3. Nur Samsu

In Pathology and Forensic Medicine

1. M. F. Holick
2. M. Wacker
3. AG Pittas
4. Joseph Lau
5. M. Demay
6. D. Bikle
7. K. Y. Forrest
8. W. Stuhldreher

Citations in the corpus

• Systematic Review: Vitamin D and Cardiometabolic Outcomes (2010, background): “Regarding cardiovascular outcomes, vitamin D regulates the renin–angiotensin system (46), suppresses proliferation of vascular cell smooth muscle (47), improves insulin resistance (18) and endothelial cell– dependent vasodilation (48, 49), inhibits anticoagulant activity (50) and myocardial cell hyp”
• Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “A VDRE has been identified in the promoter of the renin gene, and direct inhibition of renin expression by 1,25(OH)2D has been confirmed in vitro (586) and in vivo (121, 587).”
• Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment (2021, background): “Even the interstitial renal Ang-II levels are 1000-fold higher than in the plasma [41], so that intrarenal RAS is believed to play the major damaging role.”
• Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation (2013, background): “The production of 1,25(OH)2D in the kidney enters the circulation and is able to downregulate renin production in the kidney [148,149] and to stimulate insulin secretion in the β-islet cells of the pancreas [148,150].”
• Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. (2005, background): “Our studies provide a molecular basis to explore the potential of vitamin D analogs as therapeutic renin inhibitors (21), and warrant further investigations into the roles of vitamin D in cardiovascular health.”