Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes.

By A. Wolf, D. Wolf, H. Rumpold, Barbara Enrich, Herbert Tilg. Biochemical and Biophysical Research Communications - BBRC, 2004

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Adipocytokines: mediators linking adipose tissue, inflammation and immunity (2006, background): “3a ) and dendritic cells (DCs), and suppresses the production of interferon-γ ( IFNγ ) by LPS-stimulated human macrophage”
Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties1 (2007, background): “Adiponectin, the most abundant adipocyte protein, has potent anti-inflammatory properties by inhibiting proinflammatory TNF- and by inducing anti-inflammatory cytokines like IL-10 and IL-1 receptor antagonist (IL-1Ra) (21, 22).”
Type 2 diabetes as an inflammatory disease (2011, background): “It may exert these effects in several ways; for example, by inducing anti-inflammatory cytokines such as IL-10 and IL-1R”
Adiponectin: mechanistic insights and clinical implications (2012, background): “Also, production of the antiinflammatory cytokine, IL-10, is increased [60, 63, 64].”
Adiponectin Regulation and Function (2018, neutral): “The ability of adiponectin to suppress M1 macrophage activation and promote M2 macrophage proliferation is unclear and controversial (2,38,243,244,335,368,370,379).”
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. (2007, neutral): “IL-10 expression in human leukocytes (39).”