Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH

By E. Svastova, A. Hulikova, Monika Rafajová, M. Zat'ovicová, A. Gibadulinová, A. Casini, A. Cecchi, A. Scozzafava, Claudiu T. Supuran, J. Pastorek and 1 more. FEBS Letters, 2004

690 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ee8c43e990d1718a226db199b7c8a2d2ab5af539

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Citations in the corpus

Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. (2009, background): “be functionally linked to the regulation of the tumor pH, because it contributes to extracellular acidification (31) and forced CAIX”
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. (2007, background): “CA-IX catalyzes carbonic dioxide hydrolysis (44) to facilitate survival under conditions of hypoxia by increasing the concentration of basic equivalents in the cytoplasm, which simultaneously lowers the pH in the extracellular space, thereby creating a favorable environment for the activation of the”
Interfering with pH regulation in tumours as a therapeutic strategy (2011, background): “Two carbonic anhydrase isozymes (CA9 and CA12) are overexpressed in many tumours, and are associated with cancer progression and response to therap”
Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. (2011, background): “Similar to findings in MDCK cells expressing CAIX (30), we observed that the inhibitor was not able to bind appreciably 4T1 or 67NR”
Combination therapy in combating cancer (2017, background): “Although there are a total of 15 CA isoforms in the human body, CAIX [67, 68] and CAXII [69] isoforms have been shown to be the target of many carbonic anhydrase inhibitors (CAIs) because their overexpression in various tumors is correlated with poor survival and progression (Figure 2) [70-72].”
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “Firstly, CAIX expression was clearly shown to contribute to extracellular acidification (decreased pHo) of tumour cells in hypoxia, in a way that does not depend on lactic acid production [125].”