Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

By S. Amasheh, N. Meiri, A. Gitter, T. Schöneberg, J. Mankertz, J. Schulzke, M. Fromm. Journal of Cell Science, 2002

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View Paper: https://www.semanticscholar.org/paper/ed7acd5856955bb80286e227a12b57017fde9756

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Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease (2018, background): “2010), which has been shown to create paracellular cation-selective pores (Furuse et al. 2001; Amasheh et al. 2002; Li et al. 2014; Weber et al. 2015).”
Tight Junction Pore and Leak Pathways: A Dynamic Duo (2011, background): “Thus, although the specific role of claudins in forming paracellular pores is relatively well understood (16, 34, 37, 42, 61, 62), the manner in which claudins enhance barrier function is not.”
Regulation of intestinal epithelial permeability by tight junctions (2012, background): “For example, claudin-2 and -12, poreforming isoforms, have 3 (positions 53, 65 and 75) and 4 (positions 62, 66, 71 and 74) negatively charged amino acids, respectively, and form selective cation pores [53, 54, 62].”
Intestinal mucosal barrier function in health and disease (2009, background): “A second pathway is characterized by small pores that are thought to be defined by tight junction-associated claudin proteins, which are also primary determinants of charge selectivit”
Cytokine regulation of tight junctions (2008, background): “Increases in claudin 2 alter cell permeability, as exemplified by claudin 2 overexpression in epithelial cells, which lowers transepithelial resistance (TER) and confers increased Na+ conductance [63-65].”
Human Intestinal Barrier Function in Health and Disease (2016, background): “One reported difference is the increased expression of claudin-2, which forms cationselective channels in the paracellular space, resulting in water transportation across the TJs.(17,18) Increased expression of claudin-2 is also observed in the intestinal epithelium of inflammatory bowel disease (IB”
Physiology and function of the tight junction. (2009, background): “Claudins 2 (Furuse et al. 2001; Colegio et al. 2002; Amasheh et al. 2002) and 10 (Van Itallie et al. 2006) tend to make tight monolayers leakier.”
The tight junction: a multifunctional complex. (2004, background): “sor lethal (2) giant larvae interacts with basolateral exocytic machinery in”
Structure and function of claudins. (2008, background): “On the other hand, pore forming claudin-2 [9], -15 [52], or -16 [10] may facilitate paracellular cation permeability when transfected in pore-containing epithelia.”