Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

By Mahesh N. Sangrithi, J. A. Bernal, M. Madine, A. Philpott, Joon-Kyu Lee, W. G. Dunphy, A. Venkitaraman. 2005

300 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. W. G. Dunphy
2. A. Kumagai
3. Y. Kubota
4. Hiroyuki Araki
5. H. Takisawa

In Molecular Biology

1. A. Kumagai
2. W. G. Dunphy
3. Y. Kubota
4. Hiroyuki Araki
5. H. Takisawa
6. Andrej Shevchenko

Citations in the corpus

• Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1 (2021, background): “While the interaction with ATR is mediated by a predominantly unstructured ATR-activating domain (AAD) near the C-terminus of TOPBP1/Dpb11/Rad4 [103–105], the link to 9–1–1 is mediated by binding of the phosphorylated C-terminus of RAD9/Ddc1/Rad9 [101,106,107] to one or other of the upstream BRCT do”
• Efficient Initiation of DNA Replication in Eukaryotes Requires Dpb11/TopBP1-GINS Interaction (2013, background): “However, it is unknown which part of TopBP1 can associate with RecQL4; moreover, RecQL4 is not required for the loading of GINS onto chromatin (21, 22).”
• DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans (2023, unknown): “Moreover, the RECQL4 helicase has an amino-terminal region with homology to yeast Sld2 and is important for replication in Drosophila (27), Xenopus laevis egg extracts (28), and chicken DT40 cells (29), yet studies of Xenopus RECQL4 indicate a role after CMG assembly rather than before (28, 30).”
• Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication (2010, background): “This protein is necessary for DNA replication in Xenopus egg extracts and human tissue culture cells (Matsuno et al., 2006; Sangrithi et al., 2005).”
• The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication (2006, background): “During the course of our study, Ashok Venkitaraman (Cancer Research UK) and his colleagues reported that human and Xenopus RecQ4 are essential for chromosomal DNA replication and showed that mutation in the helicase domain of RecQ4 led to loss of its activity in rescuing DNA replication in RecQ4depl”
• MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication (2017, background): “Vertebrate RecQ4 displays limited sequence homology with Sld2, but the available evidence suggests that it is not a target of S-Cdk for initiation (Sangrithi et al., 2005; Matsuno et al., 2006).”