Efficient Initiation of DNA Replication in Eukaryotes Requires Dpb11/TopBP1-GINS Interaction

By Seiji Tanaka, Y. Komeda, Toshiko Umemori, Y. Kubota, H. Takisawa, Hiroyuki Araki. 2013

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In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, background): “TOPBP1 in turn contacts GINS ( 16 ).”
Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1 (2021, unknown): “[61], TRESLIN [80], GINS [115], BLM [63],”
DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation (2023, background): “TopBP1 also contains a GINS interacting motif (GINI), which lies between BRCT3 and BRCT4 domains ( 52 ), and was proposed recently to interact directly with GINS using BRCT4 + 5 domains ( 53 ).”
DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans (2023, unknown): “In this way, Dpb11 bridges phospho-Sld3 and Cdc45 on Mcm2-7 double hexamers to phospho-Sld2 that associates with GINS and DNA polymerase e (20, 21), leading to the formation of a preinitiation complex (step 4 in fig.”
Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation (2023, unknown): “…the phosphorylated Sld2 forms a sub-complex with Dpb11, GINS, and Pole (the pre-loading complex, pre-LC), while the phosphorylated Sld3 recruits pre-LC via the interaction with Dpb11 to form the preinitiation complex (pre-IC; Muramatsu et al, 2010; Heller et al, 2011; Tanaka et al, 2013).”