MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication

By A. Kumagai, W. G. Dunphy. 2017

44 citations recorded by the source corpus.

MTBP, the partner of Treslin, contains a novel DNA-binding domain that associates with double-stranded DNA and G-quadruplex DNA. Mutants of MTBP that lack a functional version of this domain cannot support normal initiation of DNA replication.

Subfields: Industrial relations

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1. Yang Lim
2. L. Tamayo-Orrego
3. Ernst W. Schmid
4. O. V. Kochenova
5. Zygimante Tarnauskaite
6. Sachiko Muramatsu
7. Rhian Gruar
8. Gheorghe Chistol

Citations in the corpus

• In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, background): “Indeed,knock-downofMTBPorTRESLIN, which act upstream of DONSON, reduces origin firing and increases fork rates, but unlike DONSON, does not cause fork asymmetry ( 11 , 12 , 47 ).”