The N-Terminal Noncatalytic Region of Xenopus RecQ4 Is Required for Chromatin Binding of DNA Polymerase α in the Initiation of DNA Replication

By K. Matsuno, Maya Kumano, Y. Kubota, Yoshitami Hashimoto, H. Takisawa. 2006

191 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

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In Molecular Biology

Citations in the corpus

In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, background): “However, a central mystery concerns the metazoan counterpart of Sld2 because RECQL4, the closest vertebrate homolog of Sld2, functions after CMG assembly ( 17 , 18 ).”
Efficient Initiation of DNA Replication in Eukaryotes Requires Dpb11/TopBP1-GINS Interaction (2013, background): “However, it is unknown which part of TopBP1 can associate with RecQL4; moreover, RecQL4 is not required for the loading of GINS onto chromatin (21, 22).”
Novel role of DONSON in CMG helicase assembly during vertebrate DNA replication initiation (2023, unknown): “MCM10 mediates the RecQL4 association with CMG helicase (Xu et al, 2009), and RecQL4 is required for Pola loading during replication initiation (Sangrithi et al, 2005; Matsuno et al, 2006).”
DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans (2023, unknown): “…in Drosophila (27), Xenopus laevis egg extracts (28) and chicken DT40 cells (29), yet studies of Xenopus RECQL4 indicate a role after CMG assembly rather than before (28, E u r op e P M C F und e r s A u t ho r M a nu s c r i p t s E u r op e P M C F und e r s A u t ho r M a nu s c r i p t s 30).”
DONSON facilitates Cdc45 and GINS chromatin association and is essential for DNA replication initiation (2023, background): “Interestingly, although BRCT4 + 5 are homologous to fungal BRCT3 + 4, it is BRCT7 + 8 that binds RecQ4, but this interaction is not dependent on CDK phosphorylation in either species ( 21 , 54 ).”
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. (2010, background): “Consistent with this conclusion, CDK phosphorylation is required for formation of the yeast Sld2–Dpb11 complex but not the vertebrate counterpart RECQL4–TopBP1 (Matsuno et al. 2006; Tanaka et al. 2007; Zegerman and Diffley 2007).”
MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication (2017, background): “Vertebrate RecQ4 displays limited sequence homology with Sld2, but the available evidence suggests that it is not a target of S-Cdk for initiation (Sangrithi et al., 2005; Matsuno et al., 2006).”
Treslin Collaborates with TopBP1 in Triggering the Initiation of DNA Replication (2010, background): “This protein is necessary for DNA replication in Xenopus egg extracts and human tissue culture cells (Matsuno et al., 2006; Sangrithi et al., 2005).”