Role of quinones in toxicology.

By J. Bolton, M. Trush, Trevor M. Penning, G. Dryhurst, T. Monks. Chemical Research in Toxicology, 2000

1,603 citations recorded by the source corpus.

Subfields: Organic Chemistry, Toxicology

View Paper: https://www.semanticscholar.org/paper/ed5731ef177e2a0cb28d9c5b5c4b8751641aca27

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In Organic Chemistry

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Citations in the corpus

• The oxidative environment and protein damage. (2005, background): “The chemistry of these quinone/semiquinone/diol systems has been reviewed [125,126].”
• Induction of phase I, II and III drug metabolism/transport by xenobiotics (2005, background): “…conjugated with glutathione (GSH) catalyzed by various GSTs, and have been implicated with the potential of forming reactive intermediates in particular when GSH levels in the cells are attenuated, consequently resulting in toxicological effects (Bolton and Chang, 2001; Bolton et aL, 2000).”
• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “As indicated earlier, these estrogens are oxidized to o-quinones which are electrophiles as well as potent redox active compounds (Bolton et al., 2000).”
• Review on in vivo and in vitro methods evaluation of antioxidant activity (2012, background): “…neural disorders (Sas et al., 2007), Alzheimer’s disease (Smith et al., 2000), mild cognitive impairment (Guidi et al., 2006), Parkinson’s disease (Bolton et al., 2000), alcohol induced liver disease (Arteel, 2003), ulcerative colitis (Ramakrishna et al., 1997), aging (Hyun et al., 2006) and…”
• Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. (2005, methodology): “Activation through PAH-o-quinone Similar to the metabolic mechanism currently presented for estrogens via catechols (Bolton et al., 1998, 2000), the formation of o-quinones by dihydrodiol dehydrogenases (DD)-catalyzed oxidation was proposed in the late 1980s of the last century as the 3rd major…”
• Oxidative Stress and Air Pollution Exposure (2011, background): “are highly reactive molecules and, by means of redox cycling, produce ROS [49].”
• Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. (2014, background): “Chemical agents like quinones (33); heavy metals such as lead, arsenic, mercury, chromium, and cadmium; organic solvents; and pesticides are common exogenous sources of ROS (331).”
• Polycyclic Aromatic Hydrocarbons (2002, background): “2007, 2011) and the reactive oxygen species (ROS) production, caused by oxidative derivatives of PAHs (Bolton et al. 2000).”
• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, neutral): “Exposure to xenobiotics that are quinone-based or give rise to quinones or quinoneimines is also a cause of oxidative stress through one-electron and two-electron redox cycling [18].”
• Airborne Particulate Matter and Human Health: Toxicological Assessment and Importance of Size and Composition of Particles for Oxidative Damage and Carcinogenic Mechanisms (2008, background): “The role of quinones in toxicology through their redox potential and the formation of ROS has been studied extensively (108).”