Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

By Quint le Duc, Quanming Shi, Iris Blonk, A. Sonnenberg, Ning Wang, D. Leckband, J. de Rooij. Journal of Cell Biology, 2010

643 citations recorded by the source corpus.

Vinculin localizes to tension-bearing cell–cell junctions to help transmit signals from E-cadherin to the actin cytoskeleton in response to mechanical stress.

Subfields: Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/7670d363fe578a1652cf15fbde9c62556f2fdd97

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Erik Sahai
2. X. Trepat

Citations in the corpus

• Dynamic molecular processes mediate cellular mechanotransduction (2011, neutral): “Although the other molecular players are different, vinculin is recruited to both structures in a myosin-dependent manner, thereby contributing to adhesion strengthenin”
• A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion (2017, background): “Three classes of duration time were defined: longer than 60 min (>60), between 30 to 60 min (30-60) and less than 30 min (<30).”