DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

By Hien G. Tran, A. Brunet, Jill M. Grenier, Sandeep R. Datta, A. Fornace, P. Distefano, Lillian W. Chiang, Michael E. Greenberg. Science, 2002

899 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ed05aa70a5701fd4551d0ae3dc3609273a66cbda

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Citations in the corpus

• p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, background): “An interesting parallel situation may be found in the role of mammalian FOXO3a in cell survival; some FOXO3a-regulated genes promote cell survival, while other genes promote apoptosis [36,37].”
• FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. (2007, background): “…the oxidative stress response is regulated in part by FoxO induction of MnSOD, catalase, and GADD45 (Kops et al., 2002a; Nemoto and Finkel, 2002; Tran et al., 2002), and has been linked to longevity and dauer formation in C. elegans (Honda and Honda, 1999; Lee et al., 2003; Murphy et al., 2003).”
• Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets (2011, unknown): “Foxo3a has been also shown to control insulin sensitivity and influence energy metabolism 39,40 .”
• The plasticity of aging: insights from long-lived mutants. (2005, background): “Likewise, mammalian FOXO proteins activate stress-response genes when insulin or IGF-1 levels are reduced (Kops et al., 2002; Nemoto and Finkel, 2002; Tran et al., 2002).”
• FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “In addition, FOXO proteins have been reported to allow detoxification of reactive oxygen species (ROS) by upregulating the free radical scavenging enzymes, including Mn superoxide dismutase (MnSOD) and catalase (Kops et al., 2002a; Nemoto and Finkel, 2002; Ramaswamy et al., 2002; Tran et al., 2002).”
• Mammalian SIRT1 represses forkhead transcription factors. (2004, background): “Expression vectors for Foxo3a, or Foxo3a repair (Tran et al., 2002; Furukawa-Hibi et al., 2002) and plus SIRT1 or SIRT1dn, were also transfected, as indioxidative stress resistance (Murphy et al., 2003; Kops cated (Figure 2A).”