Hippocampal volume reduction in major depression.

By J. Douglas Bremner, Meena Narayan, Eric R. Anderson, Lawrence H. Staib, H. Miller, Dennis S. Charney, K. Colonese, Jacque Piscitelli, Lisa M Roach. American Journal of Psychiatry, 2000

1,729 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/eccabfb80763edfa48c5f6ed0ec412e17f3a4781

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Pharmacology

Citations in the corpus

Depression: perspectives from affective neuroscience. (2002, result): “…cohorts [e.g., Vakili et al. (2000): 38 ± 10 years vs. Sheline et al. (1996): 69 ± 10 years; von Gunten et al. (2000): 58 ± 9 years; Steffens et al. (2000): 72 ± 8 years] or less severe and less chronic cohorts (Ashtari et al. 1999 vs. Sheline et al. 1996, Shah et al. 1998, Bremner et al. 2000).”
Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories (2007, methodology): “Figure 2c shows that significantly less BDNF was expressed in LVCre as compared with LV-GFP-infected brains in the dentate gyrus (DG) t(25) = 4.”
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. (2000, background): “More recently, there has been interest in the fact that major and prolonged depression appears to also involve morphological changes in the brain (Bremner et al 2000; Sheline et al 1996, 1999).”
Life stress, the "kindling" hypothesis, and the recurrence of depression: considerations from a life stress perspective. (2005, background): “…and recurrent depressed patients versus nondepressed individuals, assumed to result from the toxic effects of stress hormones (e.g., glucocorticoids; Bremner et al., 2000; Shah, Ebmeier, Glabus, & Goodwin, 1998; Sheline, Sanghavi, Mintun, & Gado, 1999; Sheline, Wang, Gado, Csernansky, & Vannier,…”
Lower hippocampal volume in patients suffering from depression: a meta-analysis. (2004, background): “When evaluated as a group, studies measuring hippocampal volume by using MRI scans in the coronal or tilted coronal orientation (eight studies [3–7, 20, 23, 25]) retained significance (left hippocampus: 95% CI of z scores=–0.”
Antidepressants increase neural progenitor cells in the human hippocampus (2009, background): “Smaller hippocampal volume has been reported in MDD (Sheline et al, 1999; Bremner et al, 2000), together with apoptosis in neuronal cells of the entorhinal cortex, subiculum, DG, CA1, and CA4 regions of the hippocampus (Lucassen et al, 2001).”
Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “…evidence also suggested that the degree of hippocampal atrophy or hippocampal volume loss is determined by the duration of the depressive illness, suggesting that stress cascades progressively thin out hippocampal dendritic spines (Bremner et al., 2000; Sheline, Sanghavi, Mintun, & Gado, 1999).”
Decreased serum brain-derived neurotrophic factor levels in major depressed patients. (2002, background): “In parallel, neuroimaging studies have reported structural changes in major depression, leading to a neuronal morphologic approach to human depression (Sheline et al., 1996; Bremer et al., 2000; Rajkowska et al., 1999; Rajkowska, 2000).”
Testing Predictions From Personality Neuroscience: Brain Structure and the Big Five (2010, background): “In addition, reduced hippocampal volume has been associated with stress and depression (Bremner et al., 2000).”
Neurobiology of emotion perception II: Implications for major psychiatric disorders. (2003, background): “…et al 2002), and the subgenual region of the anterior cingulate gyrus (Botteron et al 2002; Drevets et al 1997), as well as the hippocampus (Bremner et al 2000; Sheline et al 1999), the putamen (Husain et al 1991), the caudate nucleus (Krishnan et al 1992), and the amygdala (Sheline et al…”
The link between childhood trauma and depression: insights from HPA axis studies in humans. (2008, positive): “Patients with major depression and PTSD exhibit decreased hippocampal volume (e.g., Sheline et al., 1996; Bremner et al., 2000; Frodl et al., 2002), although findings are not uniformly consistent (e.g., Vakili et al., 2000; Rusch et al., 2001).”