Inflammasomes in health and disease

By T. Strowig, Jorge Henao-Mejia, Eran Elinav, R. Flavell. Nature, 2012

2,173 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ec7aa39a9427e9862702d30e67129935c5afdadf

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Citations in the corpus

Role of pyroptosis in inflammation and cancer (2022, background): “Several immune-mediated diseases in humans have been associated with mutations in components of inflammasome complexes [28].”
NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation and fibrosis (2014, background): “NLRP3 inflammasome activation governs the cleavage and activation of Casp1 resulting in maturation of effector pro-inflammatory cytokines such as pro-IL-1β and pro-IL-18.(2-4)”
TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria (2012, positive): “Despite the identification of numerous triggers, direct binding of any ligands to NLRP3 has not been clearly demonstrated (Strowig et al., 2012).”
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). (2016, background): “As part of the innate immune system activity, inflammasomes contribute to immune activation in response to different stimuli [59].”
Mechanisms and functions of inflammasomes. (2014, background): “Therapeutic Potential of Inflammasome Modulation Aberrant inflammasome signaling contributes to pathology in a large number of infectious (Lamkanfi and Dixit, 2011) and autoimmune diseases (Lamkanfi and Dixit, 2012; Strowig et al., 2012).”
NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases (2015, background): “…LRR, leucine-rich-repeat olymorphonuclear leukocytes; POP, PYD-only proteins; PRRs, pattern-recognition MCs, smooth muscle cells; TLRs, toll-like receptors; TNF, tumor necrosis factor; Trx, unfolded protein response eing Biology (B2A), UMR-8256/INSERM ERL-1164, Université Pierre et Marie Curie,”
Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation* (2012, background): “NLRP3 is critical for innate immunity against pathogens (1), but inappropriate activation of NLRP3 has been implicated in the pathogenesis of a number of human diseases, including gouty arthritis, silicosis, and neurodegeneration, and inmanymetabolic disorders, such as atherosclerosis, type 2 diabet”
Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “…inflammasome is therefore involved in the pathogenesis of several inflammatory disorders, including type-2 diabetes (T2D), atherosclerosis, gout, and Alzheimer’s disease, suggesting that this activation needs to be tightly controlled (Guo et al., 2015; Schroder et al., 2010; Strowig et al., 2012).”
Mechanism and regulation of NLRP3 inflammasome activation (2016, background): “However, dysregulated activation of the NLRP3 inflammasome has been implicated in the pathogenesis of inherited and acquired inflammatory diseases [10,11].”
The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases (2016, background): “Besides, the activation of inflammasome followed by ROS production has been implicated in regulating proinflammatory cytokines, IL-1β and IL18 production; it requires TLR ligands such as LPS for gene synthesis and second stimulus produced by DAMP for cleavage of caspase-1, which further stimulates t”
Cellular and Molecular Players in Adipose Tissue Inflammation in the Development of Obesity-induced Insulin Resistance (2013, neutral): “The inflammasome is an intracellularmultimeric complex that plays an important role in innate immunity [127].”