Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

By M. Nguyen, R. Marcellus, A. Roulston, M. Watson, L. Serfass, S. R. Murthy Madiraju, D. Goulet, J. Viallet, L. Bélec, Xavier Billot and 7 more. Proceedings of the National Academy of Sciences of the United States of America, 2007

663 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/ec7975cc966a1dfcb9f7a0b9b11b72ec84a44626

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Guido Kroemer
2. L. Galluzzi
3. Simone Fulda
4. K. Yip
5. John Calvin Reed
6. P. Colman
7. P. Czabotar
8. G. Lessene

In Oncology

1. Guido Kroemer
2. L. Galluzzi
3. John Calvin Reed
4. P. Czabotar
5. Simone Fulda
6. Rebecca S. Y. Wong

Citations in the corpus

• Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms (2009, neutral): “B and C) (Nguyen et al., 2007).”
• Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations (2015, neutral): “Plasticity of the protein surface allows recognition of diverse chemical scaffolds There have been dozens of reported inhibitors of Bcl-2 family members (18, 19, 97-115), spanning a broad range of chemotypes.”
• BCL-2 family antagonists for cancer therapy (2008, result): “Other results suggest K i values in the range of 1–7 μ”
• Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL (2016, neutral): “26).”
• Bcl-2 family proteins and cancer (2008, background): “Several chemical inhibitors of antiapoptotic Bcl-2-family proteins based on mimicking BH3 peptides have been described (Wang et al., 2000a, b; Degterev et al., 2001; Enyedy et al., 2001; Tzung et al., 2001; Kutzki et al., 2002; Leone et al., 2003; Becattini et al., 2004; Pellecchia and Reed, 2004; W”
• Targeting mitochondria for cancer therapy (2010, background): “Obatoclax (GX15-070) is a small-molecule indole bipyrrole compound that — similarly to gossypol — antagonizes BCL-2, BCL-X L , BCL-W and MCL1 (Ref”