Low excitatory innervation balances high intrinsic excitability of immature dentate neurons
By Cristina V. Dieni, R. Panichi, James Bradley Aimone, C. Kuo, Jacques I. Wadiche, Linda Overstreet-Wadiche. 2016
81 citations recorded by the source corpus.
Persistent neurogenesis in the dentate gyrus produces immature neurons with high intrinsic excitability and low levels of inhibition that are predicted to be more broadly responsive to afferent activity than mature neurons. Mounting evidence suggests that these immature neurons are necessary for generating distinct neural representations of similar contexts, but it is unclear how broadly responsive neurons help distinguish between similar patterns of afferent activity. Here we show that stimulation of the entorhinal cortex in mouse brain slices paradoxically generates spiking of mature neurons in the absence of immature neuron spiking. Immature neurons with high intrinsic excitability fail to spike due to insufficient excitatory drive that results from low innervation rather than silent synapses or low release probability. Our results suggest that low synaptic connectivity prevents immature neurons from responding broadly to cortical activity, potentially enabling excitable immature neurons to contribute to sparse and orthogonal dentate representations. Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience
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Citations in the corpus
- Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “Consistent with this view, immature adult-born granule cells, which receive significantly fewer perforant path inputs (Dieni et al., 2016) receive reduced synaptic inhibition (Li et al.”
- Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, unknown): “…DG excitability; experiments in hippocampal slices suggest that immature adult-born neurons are poorly coupled to inhibitory neurons in the DG and hilus (Temprana et al., 2015) while being subject to feedback and feedforward inhibitory inputs themselves (Dieni et al., 2016; Li et al., 2012, 2013b).”
- Constitutive and Synaptic Activation of GIRK Channels Differentiates Mature and Newborn Dentate Granule Cells (2018, background): “The inverse relationship between intrinsic excitability and synaptic integra- tion suggests that the high excitability of immature GCs is counteracted by low excitatory innervation (Dieni et al., 2013b, 2016; Li et al., 2017).”