LPS induction of gene expression in human monocytes.

By M. Guha, N. Mackman. Cellular Signalling, 2001

2,415 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/eb6e6badffbac319004ac0f99c4ff2b10746d62d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Immunology

In Oncology

Citations in the corpus

The IκB Kinase Complex and NF-κB Actas Master Regulators of Lipopolysaccharide-Induced Gene Expressionand Control Subordinate Activation ofAP-1 (2004, background): “Whereas MAPK signaling involves phosphorylation of ERKs, JNKs, and p38 members and the subsequent activation of transcription factor Elk1, AP-1, SRF, or CREB, activation of IKK induces nuclear translocation and DNA binding of NF- B (17).”
The inflammatory response in stroke. (2007, background): “Activated leukocytes, especially neutrophils, result in further damage of ischemic lesions through reperfusion or secondary injury mechanisms (Guha and Mackman, 2001).”
Macrophage activation and polarization. (2008, background): “LPS is the principal component of the outer membrane of Gram-negative bacteria, it is recognized by the plasmatic LPS-binding protein and delivered to a cell surface receptor complex constituted by CD14, the transmembrane signaling receptor toll-like receptor 4, and its accessory protein MD2 (18).”
Beta-caryophyllene is a dietary cannabinoid (2008, background): “CB2 receptor agonists have repeatedly been shown to inhibit the release of cytokines from LPSstimulated monocytes, such as tumor necrosis factor- (TNF- ) (14, 28, 29).”
Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, methodology): “We thank the fellowship for LCG (207760), provided by the Consejo Nacional de Ciencia y Tecnología (CONACyT), Mexico, and the FNS (31-46833) and the Ligue Pulmonaire Genevoise.”
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms (2004, background): “In addition, I B kinase (IKK ) has recently been proposed to be involved in cytokine- and obesity-induced insulin resistance through decreasing phosphorylation of IR (57), and LPS is known to activate the IKK/NF- B pathway (16).”
Extracting a Cellular Hierarchy from High-dimensional Cytometry Data with SPADE (2011, positive): “Similar signaling biology has been reported in neutrophils, which are the terminally differentiated progeny of myelocytes [19], but never directly reported in the bone marrow.”
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice (2002, methodology): “To exclude the possibility that IL-10 used in our experiments was contaminated with LPS, which has been shown to activate p38 as well as ERK and JNK (ref”