Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

By Tzong-Shyuan Lee, L. Chau. Nature Medicine, 2002

1,066 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eb38bd44ee5e063b19554ad436e249e77c4fe502

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In Critical Care and Intensive Care Medicine

1. Carol A. Colton

In Genetics

1. Carol A. Colton
2. Shizuo Akira

In Molecular Biology

1. Rui Wang
2. N. Wakabayashi
3. T. Kensler
4. Stephen L. Slocum
5. J. Skoko
6. Soona Shin
7. T. Hirano
8. J. Liao

Citations in the corpus

• Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain (2009, background): “IL10’s protective effects are mediated, in part, by heme oxygenase 1 (HO-1; Lee and Chau 2002; Weis et al. 2009).”
• Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. (2008, background): “Biliverdin is then converted to the antioxidant bilirubin [89].”
• Nitric oxide and redox mechanisms in the immune response (2011, positive): “The synergistic action of HO-1 helps to re-enforce the suppression of proinflammatory factors such as iNOS, MPO, and COX by degrading these heme-containing enzymes.”
• Mechanisms of cell protection by heme oxygenase-1. (2010, background): “In addition, several molecules produced under physiologic conditions might act in a similar manner, including the anti-inflammatory cytokine interleukin-10 (55), 15-deoxy-12, 14-prostaglandin J2 (56), vascular endothelial growth factor (57, 58), stromal cell-derived factor 1 (59), nitric oxide (NO) ”
• Interleukin-10 Therapy—Review of a New Approach (2003, background): “Blocking HO-1 by zinc protoporphyrin attenuated the IL-10-mediated protection against endotoxin-induced septic shock in mice, suggesting HO-1 might be an important downstream effector of IL-10 (Lee and Chau, 2002).”
• Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications (2005, background): “Interleukin-10, in turn, induces HO-1 expression and the latter produces more CO (Lee and Chau, 2002).”
• Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles (2014, neutral): “HO-1 [34–36] and IL-10 expressed in macrophages plays a crucial role in preventing colitis due to their potent anti-inflammatory capacity[37, 38][36, 37] [31, 32].”
• Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. (2006, background): “Interestingly, the anti-inflammatory cytokine IL-10 can also stimulate ho-1 in macro- Physiol Rev • VOL 86 • APRIL 2006 • www.prv.org by 10.220.33.3 on O ctober 27, 2017 http://physrev.physiology.org/ D ow nloaded from phages (367).”
• When NRF2 Talks, Who's Listening? (2010, positive): “The NF-kB target IL-10 (15) has been shown to induce HO-1 in murine macrophages and in vivo (87).”
• IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages (2003, background): “SOCS3 deficiency and endotoxin shock Whereas IL-10 suppresses inflammation in models of acute inflammatory disorders, such as LPS-induced endotoxin shoc”