Pleiotropic effects of statins

By J. Farmer. Current Atherosclerosis Reports, 2000

1,301 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Surgery

View Paper: https://www.semanticscholar.org/paper/eb1931657f7f1508e96b74572063a75d78de0ecc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Computational Theory and Mathematics

1. J. Liao
2. I. Graham
3. U. Förstermann
4. J. Breslow
5. W. Sessa
6. Ulrich Laufs

In Surgery

1. I. Graham
2. J. Liao
3. U. Förstermann
4. J. Breslow
5. W. Sessa
6. Ulrich Laufs

Citations in the corpus

• n-3 fatty acids and cardiovascular disease. (2006, background): “Statin therapy acts principally to lower LDL cholesterol, which in turn slows plaque progression and stabilizes plaque morphology, although many other nonlipid-lowering roles for statins have been proposed (44).”
• Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis (2016, neutral): “lowering, beneficial cardiovascular effects of this class of cardiovascular drugs.(178,179)”
• The role of inflammation in CNS injury and disease (2006, background): “For example, the Heart Protection Study reported a 28% reduction in ischaemic strokes in 20,000 people with cerebrovascular disease (Liao & Laufs, 2005).”
• Risk of complications of pregnancy in women with type 1 diabetes: nationwide prospective study in the Netherlands (2004, neutral): “Other‡ 116 512 (15) 11 050 (14) 105 462 (15)”
• Pleiotropic effects of statin therapy: molecular mechanisms and clinical results. (2008, background): “inhibited and the downstream activation of ROCK is reduced [44].”
• Nitric oxide synthases: regulation and function. (2012, background): “These properties include the improvement of endothelial function, stabilization of atherosclerotic plaques, inhibition of oxidative stress and inflammation, and reduction in thrombogenic responses.(146) These effects of statins are, in part, mediated by an effect on eNOS, because they can be inhibit”
• Pleiotropic Effects of Statins on the Cardiovascular System (2017, background): “LDL-C–dependent and LDL-C–independent (or pleiotropic) effects.(18) Clinical studies show statin benefits in diseases that”
• 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. (2016, background): “Although the reduction of LDL-C is the major effect of statins, a number of other, potentially important effects have been suggested (pleiotropic effects of statins).(201,202) Among such effects that are potentially relevant for the prevention of CVD are anti-inflammatory and anti-oxidant effects of”
• Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20 (2008, background): “Statins are structurally related, but they have several unique pharmacodynamic properties that result in pleiotropic, presumably HMG-CoAR–independent effects [28].”
• Mammalian Krüppel-Like Factors in Health and Diseases (2010, neutral): “426), which protect against atherosclerosis (24, 249).”