Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.

By John R. Jeffers, E. Parganas, Youngsoo Lee, Chunying Yang, Jinling Wang, Jennifer A. Brennan, K. Maclean, Jiawen Han, T. Chittenden, J. Ihle and 3 more. Cancer Cell, 2003

928 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/eab4562a830240ebf8194361379de0e6700d605b

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Citations in the corpus

The antioxidant function of the p53 tumor suppressor (2005, background): “, produces no significant increase in tumor frequenc”
TIGAR, a p53-inducible regulator of glycolysis and apoptosis. (2006, background): “, 1995), and the expression of the BH3-domain protein PUMA is an essential component of p53-activated apoptotic pathways in several cell types (Jeffers et al., 2003; Villunger et al., 2003).”
Tumour suppression by p53: a role for the DNA damage response? (2009, background): “, which is the crucial mediator of apoptosis in haematopoietic cell”
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression. (2016, background): “The role of Puma has been tested in knockout mouse and is critical for p53-mediated apoptosis in thymus, spleen, and intestine after ionizing irradiation (Jeffers et al. 2003).”
ER stress triggers apoptosis by activating BH3-only protein Bim. (2007, background): “For example, noxa and puma/bbc3 were discovered as p53-inducible genes (Vousden and Lu, 2002) and are now known to be essential for DNA damage-induced apoptosis (Jeffers et al., 2003; Villunger Cell 129, 1337–1349, June 29, 2007 ª2007 Elsevier Inc. 1337 et al., 2003).”
Radiation-induced cell death mechanisms (2010, background): “Puma has been shown to be essential for cell death triggered by ionizing radiation in hematopoietic cells; cells of the developing nervous system [ 45 ], fibroblasts, and thymocytes [44]; and in lymphoid cells [43].”
C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage (2005, background): “Mice lacking a functional PUMA gene are severely impaired in apoptosis of hematopoietic cells, fibroblasts, and neurons, following exposure to ionizing radiation (IR), suggesting that PUMA is an important cell death target of p53.(24,25) Mice harboring a deletion of Noxa may also be deficient in IRi”
Life in the balance: how BH3-only proteins induce apoptosis. (2005, methodology): “This paper is important because, along with [21 ], it shows that Puma and, to a lesser extent, Noxa are central mediators of p53-induced apoptosis and that Puma is also critical for several other non-p53dependent cytotoxic signals.”
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006, background): “In human cells, p53 requires both BAX and PUMA to efficiently induce apoptosis (Chipuk et al., 2003; Jeffers et al., 2003; Villunger et al., 2003; Yu et al., 2003; Zhang et al., 2000).”
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. (2006, background): “…either because a prosurvival family member is overexpressed (Cory et al., 2003), or because mutations in the p53 pathway ablate induction by p53 of the BH3-only proteins Puma and Noxa, which would otherwise trigger apoptosis (Jeffers et al., 2003; Shibue et al., 2003; Villunger et al., 2003).”