Candida albicans pathogenicity mechanisms
By François L. Mayer, Duncan W. Wilson, Bernhard Hube. Virulence, 2013
1,857 citations recorded by the source corpus.
The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to the pathogenic potential of this fungus. Among them are molecules which mediate adhesion to and invasion into host cells, the secretion of hydrolases, the yeast-to-hypha transition, contact sensing and thigmotropism, biofilm formation, phenotypic switching and a range of fitness attributes. Our understanding of when and how these mechanisms and factors contribute to infection has significantly increased during the last years. In addition, novel virulence mechanisms have recently been discovered. In this review we present an update on our current understanding of the pathogenicity mechanisms of this important human pathogen.
Subfields: Epidemiology, Food Science, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/ea82d70b2925d03c8aa23ad612a18cdb8c6906ed
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Citations in the corpus
- Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview (2017, background): “Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.”
- Candida albicans—The Virulence Factors and Clinical Manifestations of Infection (2021, background): “The transition from yeast to the hyphal form is a transition into a pathogenic form [22,23].”
- Activity of phenolic compounds from plant origin against Candida species (2015, background): “This mechanism is not only incited by yeast growth ut also by the hyphal formation (Lu et al., 2006; Mayer et al., 2013; yk et al., 2009).”
- The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data (2016, background): “As a result of medical progress, particularly with respect to chemotherapy, organ transplantation, intensive care and neonatal care, the population of immunocompromised patients susceptible to fungal infection, is expanding (6–8), and resistance to antifungal drugs is increasing (3,9,10).”