Impact of caloric restriction on health and survival in rhesus monkeys: the NIA study

By J. Mattison, G. S. Roth, T. Beasley, E. Tilmont, A. Handy, Richard L. Herbert, Dan L. Longo, David B. Allison, J. E. Young, M. Bryant and 5 more. Nature, 2012

1,093 citations recorded by the source corpus.

Calorie restriction (CR), a reduction of 10–40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported. We report here that a CR regimen implemented in young and older age rhesus monkeys at the National Institute on Aging (NIA) has not improved survival outcomes. Our findings contrast with an ongoing study at the Wisconsin National Primate Research Center (WNPRC), which reported improved survival associated with 30% CR initiated in adult rhesus monkeys (7–14 years) and a preliminary report with a small number of CR monkeys. Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies. The implications of the WNPRC findings were important as they extended CR findings beyond the laboratory rodent and to a long-lived primate. Our study suggests a separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate.

Subfields: Aging, Physiology

View Paper: https://www.semanticscholar.org/paper/ea5a27d823b624ac100a26b972930fba409435f1

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Citations in the corpus

Promoting Health and Longevity through Diet: from Model Organisms to Humans (2015, positive): “…trial twice daily (Table 2), which may have contributed to the Wisconsin DR monkeys having a 1.8 times lowered rate of death from any cause (Colman et al., 2014) in contrast with the absence of a difference in death rate in the NIA study (Mattison et al., 2012) (reviewed in Cava & Fontana, 2013).”
Low Protein Intake is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population (2014, neutral): “However, the effect of CR on the lifespan of nonhuman primates remains controversial and may be heavily inﬂuenced by dietary composition (Cava and Fontana, 2013; Colman et al., 2009; Fontana and Klein, 2007; Mattison et al., 2012; Mercken et al., 2013; Stein et al., 2012).”
The hallmarks of aging. (2013, background): “Consistent with the relevance of deregulated nutrient sensing as a hallmark of aging, dietary restriction (DR) increases lifespan or healthspan in all investigated eukaryote species, including nonhuman primates (Colman et al., 2009; Fontana et al., 2010; Mattison et al., 2012).”